Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.60 |
| ▸ | PTGS2 | P35354 | 8/20 | 0.54 |
| ▸ | PTGS1 | P23219 | 5/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | THPO | P40225 | 1/20 | 0.48 |
| ▸ | BLM | P54132 | 1/20 | 0.48 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.48 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15420161 | 0.84 | PTGS2 (0.69) | PTGS2PTGS1CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL24185597 | 0.81 | TP53 (0.50) | PTGS2PTGS1MAPK1CYP1A2CYP2C19 | |
| SCHEMBL16202075 | 0.81 | POLB (0.55) | LMNAPTGS2PTGS1HPGDCYP1A2 | |
| SCHEMBL597566 | 0.81 | ALDH1A1 (0.45) | LMNAPTGS2PTGS1MAPK1CYP1A2 | |
| SCHEMBL3281219 | 0.80 | MAPK1 (0.56) | PTGS1HPGDMAPK1HSD17B10CYP1A2 | |
| SCHEMBL6174608 | 0.78 | LMNA (0.70) | LMNAPTGS2PTGS1HPGDHSD17B10 | |
| SCHEMBL31503993 | 0.78 | USP1 (0.43) | PTGS2PTGS1ALDH1A1POLBMAPT | |
| SCHEMBL28236656 | 0.78 | TRPC3 (0.48) | PTGS2PTGS1HPGDMAPK1NPSR1 | |
| SCHEMBL18865550 | 0.77 | SLC34A1 (0.44) | PTGS2PTGS1NPSR1ALDH1A1MAPT | |
| SCHEMBL3560066 | 0.77 | ALDH1A1 (0.46) | LMNAPTGS2PTGS1HPGDNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8115005-B2 | Pyrazolylphenyl and pyrrolylphenyl inhibitors of LTA4H for treating inflammation | DECODE GENETICS EHF. (IS) | 2012-02-14 | — | — | US | disclosed |
| WO-2008019302-A1 | PYRAZOLYLPHENYL AND PYRROLYLPHENYL INHIBITORS OF LTA4H FOR TREATING INFLAMMATION | DECODE GENETICS EHF (IS) | 2008-02-14 | — | — | WO | disclosed |
| US-20080033013-A1 | PYRAZOLYLPHENYL AND PYRROLYLPHENYL INHIBITORS OF LTA4H FOR TREATING INFLAMMATION | DECODE GENETICS EHF. (IS) | 2008-02-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080033013-A1 | PYRAZOLYLPHENYL AND PYRROLYLPHENYL INHIBITORS OF LTA4H FOR TREATING INFLAMMATION | LTB4R2, LTC4S, LTA4H | LMNA 4465/4885PTGS2 14/4885PTGS1 20/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.