Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 1/20 | 0.33 |
| ▸ | SRC | P12931 | 2/20 | 0.33 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.33 |
| ▸ | PPARG | P37231 | 1/20 | 0.33 |
| ▸ | AXL | P30530 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | CASP1 | P29466 | 1/20 | 0.32 |
| ▸ | CASP7 | P55210 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | ACHE | P22303 | 2/20 | 0.32 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.32 |
| ▸ | KDR | P35968 | 1/20 | 0.32 |
| ▸ | EGFR | P00533 | 2/20 | 0.32 |
| ▸ | BTK | Q06187 | 2/20 | 0.32 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.32 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.32 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.31 |
| ▸ | MET | P08581 | 1/20 | 0.31 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6004343 | 0.88 | SIGMAR1 (0.36) | HRH3AXLALDH1A1CASP1CASP7 | |
| SCHEMBL6005251 | 0.87 | PDE2A (0.39) | SRCTGFBR1AXLALDH1A1CASP1 | |
| SCHEMBL6004922 | 0.86 | SLC22A12 (0.39) | SRCTGFBR1AXLALDH1A1CASP1 | |
| SCHEMBL6004262 | 0.82 | ALDH1A1 (0.36) | SRCTGFBR1AXLALDH1A1CASP1 | |
| SCHEMBL6004162 | 0.80 | ALDH1A1 (0.36) | SRCTGFBR1AXLALDH1A1CASP1 | |
| SCHEMBL6004251 | 0.80 | TGFBR1 (0.39) | TGFBR1AXLALDH1A1CASP1CASP7 | |
| SCHEMBL6004285 | 0.79 | CYP3A4 (0.46) | ALDH1A1HSD17B10 | |
| SCHEMBL6005281 | 0.78 | DDR2 (0.34) | SRCTGFBR1AXLPDGFRAKDR | |
| SCHEMBL6005265 | 0.78 | TGFBR1 (0.44) | SRCTGFBR1ALDH1A1CASP1CASP7 | |
| SCHEMBL6005366 | 0.76 | PDGFRB (0.36) | SRCTGFBR1AXLPDGFRAKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1724268-A1 | COMPOUND HAVING TGF-BETA INHIBITORY ACTIVITY AND PHARMACEUTICAL COMPOSITION CONTAINING SAME | KIRIN BEER KABUSHIKI KAISHA (JP) | 2006-11-22 | — | — | EP | disclosed |