SCHEMBL6013056

SCHEMBL6013056

CC(C)(C)[Si](C)(c1ccccc1)c1ccccc1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ESR1 P03372 3/20 0.41
ESR2 Q92731 3/20 0.41
NR1H2 P55055 3/20 0.38
NR1H3 Q13133 3/20 0.38
MAPK1 P28482 1/20 0.35
MEN1 O00255 1/20 0.33
KMT2A Q03164 1/20 0.33
MAPT P10636 1/20 0.32
TAAR1 Q96RJ0 2/20 0.32
ALDH1A1 P00352 2/20 0.32
ALOX15 P16050 1/20 0.32
SLC6A2 P23975 1/20 0.32
LMNA P02545 1/20 0.32
TSHR P16473 1/20 0.32
ALOX12 P18054 1/20 0.32
ACHE P22303 1/20 0.32
ELANE P08246 1/20 0.31
ATM Q13315 1/20 0.31
CYP3A4 P08684 1/20 0.31
AOC3 Q16853 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21120517 0.79 ESR1 (0.38) ESR1ESR2NR1H2NR1H3MAPK1
SCHEMBL15184948 0.79
SCHEMBL988384 0.78 NR1H2 (0.48) ESR1ESR2NR1H2NR1H3MAPK1
SCHEMBL15889153 0.78 ESR1 (0.41) ESR1ESR2NR1H2NR1H3MAPK1
SCHEMBL25798859 0.77 MAPK1 (0.41) ESR1ESR2NR1H2NR1H3MAPK1
SCHEMBL10569078 0.76 ESR1 (0.39) ESR1ESR2NR1H2NR1H3MAPK1
SCHEMBL104796 0.76 NR1H2 (0.45) ESR1ESR2NR1H2NR1H3MAPT
SCHEMBL17576282 0.75 ESR1 (0.35) ESR1ESR2NR1H2NR1H3MAPK1
SCHEMBL3526796 0.74 ESR1 (0.37) ESR1ESR2NR1H2NR1H3MAPK1
SCHEMBL29749402 0.74 ESR1 (0.37) ESR1ESR2NR1H2NR1H3MAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 113 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20060142516-A1 Process for the preparation of polyorganosilylated carboxylate monomers or polymers thereof SIGMA COATINGS B.V. (NL) 2006-06-29 US claimed
US-20240024489-A1 PROTECTED DISACCHARIDES, THEIR PROCESS OF PREPARATION AND THEIR USE IN THE SYNTHESIS OF ZWITTERIONIC OLIGOSACCHARIDES, AND CONJUGATES THEREOF INSTITUT PASTEUR (FR) 2024-01-25 US disclosed
US-20230347587-A1 3-D PRINTING PERIDOT PRINT LLC 2023-11-02 US disclosed
WO-2023189484-A1 INK COMPOSITION FOR ELECTRO-OPTIC APPLICATIONS, COMPOUND, ELECTRO-OPTIC FILM AND ELECTRO-OPTIC ELEMENT 住友化学株式会社 2023-10-05 WO disclosed
WO-2023192900-A1 NUCLEOSIDES AND NUCLEOTIDES WITH 3' VINYL BLOCKING GROUP USEFUL IN SEQUENCING BY SYNTHESIS ILLUMINA SINGAPORE PTE. LTD. (SG) 2023-10-05 WO disclosed
EP-4247828-A1 PROTECTED DISACCHARIDES, THEIR PROCESS OF PREPARATION AND THEIR USE IN THE SYNTHESIS OF ZWITTERIONIC OLIGOSACCHARIDES, AND CONJUGATES THEREOF Institut Pasteur (FR) 2023-09-27 EP disclosed
US-11718024-B2 3-D printing HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P. (US) 2023-08-08 US disclosed
US-11718024-B2 3-D printing HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P. (US) 2023-08-08 US disclosed
US-20230233692-A1 COMPOUNDS FOR TARGETED DEGRADATION OF RET C4 THERAPEUTICS, INC. (US) 2023-07-27 US disclosed
US-11700765-B2 Organic electroluminescent materials and devices UNIVERSAL DISPLAY CORPORATION (US) 2023-07-11 US disclosed
US-20120301817-A1 ACTINIC RAY-SENSITIVE OR RADIATION-SENSITIVE RESIN COMPOSITION, RESIST FILM USING THE COMPOSITION AND PATTERN FORMING METHOD FUJIFILM CORPORATION (JP) 2012-11-29 US disclosed
US-20110288053-A1 ANTIVIRAL PHOSPHONATE ANALOGS GILEAD SCIENCES, INC. (US) 2011-11-24 US disclosed
US-20110269707-A1 Modified nucleosides for the treatment of viral infections and abnormal cellullar proliferation PHARMASSET, INC. 2011-11-03 US disclosed
US-20110071101-A1 Nucleoside Phosphonate Analogs BOOJAMRA CONSTANTINE G 2011-03-24 US disclosed
US-20110039209-A1 COMPOUND AND PHOTORESIST COMPOSITION CONTAINING THE SAME SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2011-02-17 US disclosed
US-20100144868-A1 Novel Neuroprotective Compounds and Uses Thereof RAMOT AT AVIV UNIVERSITY LTD. (IL) 2010-06-10 US disclosed
CN-101072757-A Benzamide derivatives that act upon the glucokinase enzyme ASTRAZENECA AB (SE) 2007-11-14 CN disclosed
CN-101039915-A Phenoxy benzamide compounds with utility in the treatment of type 2 diabetes and obesity ASTRAZENECA AB (SE) 2007-09-19 CN disclosed
EP-1389214-A1 PROCESS FOR THE PREPARATION OF TRIALKYLSILYLATED CARBOXYLATE MONOMERS, THE OBTAINED TRIALKYLSILYLATED CARBOXYLATE MONOMERS AND THEIR USE IN ANTI-FOULING COATINGS SIGMA COATINGS B.V. (NL) 2004-02-18 EP disclosed
WO-2002094838-A1 PROCESS FOR THE PREPARATION OF TRIALKYLSILYLATED CARBOXYLATE MONOMERS, THE OBTAINED TRIALKYLSILYLATED CARBOXYLATE MONOMERS AND THEIR USE IN ANTI-FOULING COATINGS SIGMA COATINGS B.V. (NL) 2002-11-28 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110071101-A1 Nucleoside Phosphonate Analogs TYMP, PNP, NUDT1 ESR1 3684/4885ESR2 3434/4885NR1H2 4283/4885
US-20110288053-A1 ANTIVIRAL PHOSPHONATE ANALOGS TYMP, ITPA, PNP ESR1 3680/4885ESR2 3740/4885NR1H2 3695/4885
US-20240024489-A1 PROTECTED DISACCHARIDES, THEIR PROCESS OF PREPARATION AND THEIR USE IN THE SYNTHESIS OF ZWITTERIONIC OLIGOSACCHARIDES, AND CONJUGATES THEREOF SI, DAD1, FUT5 ESR1 4782/4885ESR2 4733/4885NR1H2 4423/4885
US-20060142516-A1 Process for the preparation of polyorganosilylated carboxylate monomers or polymers thereof C1R, C9, PCBP1 ESR1 2776/4885ESR2 3955/4885NR1H2 3015/4885
US-20100144868-A1 Novel Neuroprotective Compounds and Uses Thereof GRM2, GRIN1, GRM3 ESR1 842/4885ESR2 383/4885NR1H2 599/4885
US-20110269707-A1 Modified nucleosides for the treatment of viral infections and abnormal cellullar proliferation PNP, ALPP, XDH ESR1 2848/4885ESR2 3883/4885NR1H2 2277/4885
US-11700765-B2 Organic electroluminescent materials and devices SOD1, L1CAM, MCM2 ESR1 210/4885ESR2 104/4885NR1H2 1782/4885
US-20230233692-A1 COMPOUNDS FOR TARGETED DEGRADATION OF RET RET, HRAS, RBX1 ESR1 2598/4885ESR2 1087/4885NR1H2 3094/4885
US-20110039209-A1 COMPOUND AND PHOTORESIST COMPOSITION CONTAINING THE SAME RCOR3, RCN1, HRH4 ESR1 649/4885ESR2 1007/4885NR1H2 695/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.