Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNJ1 | P48048 | 1/20 | 0.55 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.55 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.54 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.54 |
| ▸ | MAOA | P21397 | 1/20 | 0.53 |
| ▸ | MAOB | P27338 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.50 |
| ▸ | APP | P05067 | 1/20 | 0.50 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.49 |
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.48 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6567516 | 1.00 | KCNJ1 (0.55) | KCNJ1KCNH2PTGS2PTGS1MAOA | |
| SCHEMBL1930129 | 0.83 | ALDH1A1 (0.61) | PTGS2NFE2L2ALDH1A1LMNACYP1A2 | |
| SCHEMBL7655222 | 0.83 | ACHE (0.60) | PTGS2MAOAMAOBMAPTNFE2L2 | |
| SCHEMBL322726 | 0.83 | ACHE (0.60) | PTGS2MAOAMAOBMAPTNFE2L2 | |
| SCHEMBL8021579 | 0.81 | PTGS2 (0.63) | PTGS2MAPTTLR9RAB9AALDH1A1 | |
| SCHEMBL9128800 | 0.81 | PTGS2 (0.68) | PTGS2MAPTTLR9RAB9AALDH1A1 | |
| SCHEMBL1005735 | 0.80 | PTGS2 (0.78) | PTGS2PTGS1MAOAMAOBMAPT | |
| SCHEMBL14880486 | 0.80 | PTGS2 (0.63) | KCNJ1KCNH2PTGS2PTGS1MAOA | |
| SCHEMBL1005734 | 0.80 | PTGS2 (0.78) | PTGS2PTGS1MAOAMAOBMAPT | |
| SCHEMBL14880488 | 0.80 | KCNJ1 (0.63) | KCNJ1KCNH2MAPTAPPRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0072757-A1 | Cephalosporin derivatives and their preparation | RHONE-POULENC SANTE (FR) | 1983-02-23 | — | — | EP | claimed |
| US-7045619-B2 | 2-(pyrazol-3-yl)carbapenem derivatives | SMITHKLINE BEECHAM P.L.C. (GB) | 2006-05-16 | — | — | US | disclosed |
| US-20060078503-A1 | 1,4,7,10-Tetraazacyclododecane butyltriols, processes for their production and pharmaceutical agents containing them | PLATZEK JOHANNES | 2006-04-13 | — | — | US | disclosed |
| EP-1432682-B1 | PROCESS FOR THE PREPARATION OF REPAGLINIDE | RANBAXY LAB LTD (IN) | 2005-05-25 | — | — | EP | disclosed |
| EP-1404691-A2 | METHOD FOR PRODUCING PERACYLATED 1-O-GLYCOSIDES | SCHERING AKTIENGESELLSCHAFT (DE) | 2004-04-07 | — | — | EP | disclosed |
| US-20030166923-A1 | 2-(pyrazol-3-yl)carbapenem derivatives | SMITHKLINE BEECHAM P.L.C. | 2003-09-04 | — | — | US | disclosed |
| WO-2003006474-A2 | METHOD FOR PRODUCING PERACYLATED 1-O-GLYCOSIDES | SCHERING AKTIENGESELLSCHAFT (DE) | 2003-01-23 | — | — | WO | disclosed |
| US-20020147333-A1 | 2-(pyrazol-3-yl)carbapenem derivatives | SMITHKLINE BEECHAM P.L.C. | 2002-10-10 | — | — | US | disclosed |
| EP-0823911-A1 | ESTERS OF CARBAPENEMS | SMITHKLINE BEECHAM PLC (GB) | 1998-02-18 | — | — | EP | disclosed |
| US-5612477-A | 2-(pyrazol-3-yl)carbapenem derivatives | SMITHKLINE BEECHAM P.L.C | 1997-03-18 | — | — | US | disclosed |
| US-5606051-A | 2-(pyrazol-3-yl)carbapenem derivatives | SMITHKLINE BEECHAM P.L.C. (GB) | 1997-02-25 | — | — | US | disclosed |
| WO-1996034869-A1 | ESTERS OF CARBAPENEMS | SMITHKLINE BEECHAM PLC (GB) | 1996-11-07 | — | — | WO | disclosed |
| EP-0725783-A1 | 2-(PYRAZOL-3-YL)CARBAPENEM DERIVATIVES | SMITHKLINE BEECHAM PLC (GB) | 1996-08-14 | — | — | EP | disclosed |
| WO-1995011905-A1 | 2-(PYRAZOL-3-YL)CARBAPENEM DERIVATIVES | SMITHKLINE BEECHAM PLC (GB) | 1995-05-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060078503-A1 | 1,4,7,10-Tetraazacyclododecane butyltriols, processes for their production and pharmaceutical agents containing them | UGT2B17, CYP3A7, UGT2B7 | KCNJ1 1856/4885KCNH2 1575/4885PTGS2 382/4885 |
| US-20020147333-A1 | 2-(pyrazol-3-yl)carbapenem derivatives | DPEP1, DHPS, JMJD6 | KCNJ1 1743/4885KCNH2 1263/4885PTGS2 2675/4885 |
| US-20030166923-A1 | 2-(pyrazol-3-yl)carbapenem derivatives | DHPS, DPEP1, JMJD6 | KCNJ1 1456/4885KCNH2 1102/4885PTGS2 2429/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.