Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | FAAH | O00519 | 1/20 | 0.40 |
| ▸ | MGLL | Q99685 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | MITF | O75030 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6015666 | 0.80 | PTGS2 (0.38) | MEN1KMT2ALMNAALDH1A1KDM4E | |
| SCHEMBL6015870 | 0.78 | ALDH1A1 (0.54) | MEN1KMT2ALMNAALDH1A1KDM4E | |
| SCHEMBL15485039 | 0.76 | MTNR1A (0.53) | MEN1KMT2ALMNAALDH1A1KDM4E | |
| SCHEMBL15484962 | 0.76 | LMNA (0.51) | MEN1KMT2ALMNAALDH1A1KDM4E | |
| SCHEMBL6015933 | 0.74 | HSD11B1 (0.43) | MEN1KMT2AALDH1A1KDM4EHSD17B10 | |
| SCHEMBL6015969 | 0.73 | CNR2 (0.43) | MEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL6016000 | 0.71 | CYP1A2 (0.33) | LMNAALDH1A1KDM4EHTTL3MBTL1 | |
| SCHEMBL6015703 | 0.71 | REN (0.39) | KMT2APOLB | |
| SCHEMBL6015693 | 0.71 | ALDH1A1 (0.41) | ALDH1A1HPGDHTTMAPTTP53 | |
| SCHEMBL1638688 | 0.70 | SMN1; SMN2 (0.51) | MEN1KMT2ALMNAALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7049312-B1 | Benzothiazinone and benzoxazinone compounds | ABBOTT GMBH & CO. KG (DE) | 2006-05-23 | — | — | US | claimed |
| EP-1181282-A2 | BENZOTHIAZINONE AND BENZOXAZINONE COMPOUNDS | BASF AKTIENGESELLSCHAFT (DE) | 2002-02-27 | — | — | EP | claimed |
| WO-2000075139-A2 | BENZOTHIAZINONE AND BENZOXAZINONE COMPOUNDS | BASF AKTIENGESELLSCHAFT (DE) | 2000-12-14 | — | — | WO | claimed |
| US-7049312-B1 | Benzothiazinone and benzoxazinone compounds | ABBOTT GMBH & CO. KG (DE) | 2006-05-23 | — | — | US | disclosed |