Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | FAAH | O00519 | 1/20 | 0.37 |
| ▸ | MGLL | Q99685 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6015675 | 0.84 | TDP1 (0.46) | TSHRKMT2AMEN1 | |
| SCHEMBL6015703 | 0.83 | REN (0.39) | KMT2A | |
| SCHEMBL6015787 | 0.78 | CBX7 (0.44) | TSHRGAANPSR1ALDH1A1SMN1; SMN2 | |
| SCHEMBL6015666 | 0.76 | PTGS2 (0.38) | ALDH1A1KMT2AKDM4EMEN1 | |
| SCHEMBL6015802 | 0.74 | MEN1 (0.46) | TSHRALDH1A1KMT2AKDM4EHSD17B10 | |
| SCHEMBL6015665 | 0.72 | OPRK1 (0.48) | NPSR1ALDH1A1KMT2AKDM4EHSD17B10 | |
| SCHEMBL6015693 | 0.71 | ALDH1A1 (0.41) | GAAALDH1A1 | |
| SCHEMBL6015925 | 0.70 | TSHR (0.54) | TSHRALDH1A1SMN1; SMN2RAB9AKMT2A | |
| SCHEMBL6015734 | 0.68 | KMT2A (0.50) | TSHRGAAALDH1A1KMT2AHSD17B10 | |
| SCHEMBL13118001 | 0.67 | KDM4E (0.64) | HSD11B1TSHRNPSR1ALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7049312-B1 | Benzothiazinone and benzoxazinone compounds | ABBOTT GMBH & CO. KG (DE) | 2006-05-23 | — | — | US | claimed |
| EP-1181282-A2 | BENZOTHIAZINONE AND BENZOXAZINONE COMPOUNDS | BASF AKTIENGESELLSCHAFT (DE) | 2002-02-27 | — | — | EP | claimed |
| WO-2000075139-A2 | BENZOTHIAZINONE AND BENZOXAZINONE COMPOUNDS | BASF AKTIENGESELLSCHAFT (DE) | 2000-12-14 | — | — | WO | claimed |
| US-7049312-B1 | Benzothiazinone and benzoxazinone compounds | ABBOTT GMBH & CO. KG (DE) | 2006-05-23 | — | — | US | disclosed |