Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | CHKA | P35790 | 1/20 | 0.38 |
| ▸ | DTYMK | P23919 | 1/20 | 0.37 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6015933 | 0.84 | HSD11B1 (0.43) | KMT2AMEN1TSHR | |
| SCHEMBL6015703 | 0.81 | REN (0.39) | KMT2APOLBCXCR3 | |
| SCHEMBL6015693 | 0.79 | ALDH1A1 (0.41) | — | |
| SCHEMBL6015787 | 0.78 | CBX7 (0.44) | TDP1KMT2AMEN1L3MBTL1TSHR | |
| SCHEMBL6015734 | 0.76 | KMT2A (0.50) | TDP1PTGS2KMT2AL3MBTL1TSHR | |
| SCHEMBL6015665 | 0.74 | OPRK1 (0.48) | KMT2AMEN1 | |
| SCHEMBL6015666 | 0.74 | PTGS2 (0.38) | PTGS2KMT2AMEN1POLB | |
| SCHEMBL15473912 | 0.71 | TDP1 (0.47) | TDP1PTGS2KMT2AL3MBTL1POLB | |
| SCHEMBL15473947 | 0.70 | LMNA (0.61) | TDP1PTGS2KMT2ACXCR3 | |
| SCHEMBL6016000 | 0.68 | CYP1A2 (0.33) | L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7049312-B1 | Benzothiazinone and benzoxazinone compounds | ABBOTT GMBH & CO. KG (DE) | 2006-05-23 | — | — | US | claimed |
| EP-1181282-A2 | BENZOTHIAZINONE AND BENZOXAZINONE COMPOUNDS | BASF AKTIENGESELLSCHAFT (DE) | 2002-02-27 | — | — | EP | claimed |
| WO-2000075139-A2 | BENZOTHIAZINONE AND BENZOXAZINONE COMPOUNDS | BASF AKTIENGESELLSCHAFT (DE) | 2000-12-14 | — | — | WO | claimed |
| US-7049312-B1 | Benzothiazinone and benzoxazinone compounds | ABBOTT GMBH & CO. KG (DE) | 2006-05-23 | — | — | US | disclosed |