Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 known ✓ | P04150 | 1/20 | 0.32 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | ENTPD1 | P49961 | 1/20 | 0.33 |
| ▸ | ENTPD2 | Q9Y5L3 | 1/20 | 0.33 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.33 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.33 |
| ▸ | PGR | P06401 | 1/20 | 0.32 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.32 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.32 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
| ▸ | ELANE | P08246 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29460462 | 0.89 | NR1I2 (0.35) | GPR35ENTPD1ENTPD2PTGER1NR1I2 | |
| SCHEMBL37571 | 0.89 | NR1I2 (0.35) | GPR35ENTPD1ENTPD2PTGER1NR1I2 | |
| Potassium Ion SCHEMBL23749083 | 0.86 | NR1I2 (0.33) | HTR2AL3MBTL1ENTPD1ENTPD2PTGER1 | |
| SCHEMBL6555708 | 0.84 | CYP2D6 (0.40) | GPR35HTR2AL3MBTL1NR3C1PGR | |
| SCHEMBL27345267 | 0.83 | CYP2D6 (0.40) | GPR35HTR2AL3MBTL1NR3C1PGR | |
| SCHEMBL1024286 | 0.78 | NR1I2 (0.35) | HTR2APTGER1NR1I2NR3C1PGR | |
| Sulfuric Acid SCHEMBL28020160 | 0.78 | MAPT (0.38) | HTR2APTGER1SLC2A1KDM4E | |
| SCHEMBL10790517 | 0.77 | HTR2A (0.42) | HTR2AL3MBTL1GPR84KDM4EATM | |
| SCHEMBL29720 | 0.76 | CYP2D6 (0.43) | NR3C1PGRNR3C2SLC2A1GPR84 | |
| SCHEMBL29364308 | 0.76 | CYP2D6 (0.43) | NR3C1PGRNR3C2SLC2A1GPR84 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7101900-B2 | Benzyl amidoxime derivatives, intermediate products and method for their production and use as fungicides | BASF AKTIENGESELLSCHAFT (DE) | 2006-09-05 | — | — | US | disclosed |
| US-20050187265-A1 | Novel benzyl amidoxime derivatives, intermediate products and method for their production and use as fungicides | RHEINHEIMER JOACHIM (DE) | 2005-08-25 | — | — | US | disclosed |
| US-6881742-B1 | Benzyl amidoxime derivatives, intermediate products and method for their production and use as fungicides | BASF AKTIENGESELLSCHAFT (DE) | 2005-04-19 | — | — | US | disclosed |
| US-6680402-B2 | SUCH AS N-PHENYLACETYL-2-DIFLUOROMETHOXY-6-FLUOROBENZAMIDE-O-CYCLOPROPYLMETHYL OXIME | BASF AKTIENGESELLSCHAFT (DE) | 2004-01-20 | — | — | US | disclosed |
| US-6680283-B1 | TREATMENT OF PLANTS, AND ALSO FOR THE THERAPEUTIC TREATMENT OF HUMAN DISORDERS CAUSED BY HARMFUL FUNGI, AND FOR THE VETERINARY TREATMENT OF MAMMALS | BASF AKTIENGESELLSCHAFT (DE) | 2004-01-20 | — | — | US | disclosed |
| US-6586369-B1 | Agriculture | BASF AKTIENGESELLSCHAFT (DE) | 2003-07-01 | — | — | US | disclosed |
| US-20030120085-A1 | Novel benzamidoxime derivatives, intermediates and processes for their preparation, and their use as fungicides | EICKEN KARL (DE) | 2003-06-26 | — | — | US | disclosed |
| US-6509501-B2 | Agriculture | BASF AKTIENGESELLSCHAFT (DE) | 2003-01-21 | — | — | US | disclosed |
| US-6476061-B1 | Fungicides containing pyrrolidones as their active agents | BASF AKTIENGESELLSCHAFT (DE) | 2002-11-05 | — | — | US | disclosed |
| US-20020133025-A1 | Novel benzamidoxime derivatives, intermediates and processes for their preparation, and their use as fungicides | EICKEN KARL (DE) | 2002-09-19 | — | — | US | disclosed |
| US-6420605-B1 | DIFLUOROMETHYL ETHERS OF BENZAMIDOXIME COMPOUNDS | BASF AKTIENGESELLSCHAFT (DE) | 2002-07-16 | — | — | US | disclosed |
| US-6417398-B1 | Benzamidoxim derivatives, intermediate products and methods for preparing them, and their use as fungicides | BASF AKTIENGESELLSCHAFT (DE) | 2002-07-09 | — | — | US | disclosed |
| US-6147104-A | USED IN COMBATING PARASITIC FUNGUS | BASF AKTIENGESELLSCHAFT (DE) | 2000-11-14 | — | — | US | disclosed |
| US-5998450-A | FOR PLANTS | BASF AKTIENGESELLSCHAFT (DE) | 1999-12-07 | — | — | US | disclosed |
| US-5922899-A | Carbamoyl carboxylic acid amides | BASF AKTIENGESELLSCHAFT (DE) | 1999-07-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020133025-A1 | Novel benzamidoxime derivatives, intermediates and processes for their preparation, and their use as fungicides | CBR1, CBR3, CYP1B1 | NR3C1 1861/4885GPR35 3061/4885HTR2A 3815/4885 |
| US-20050187265-A1 | Novel benzyl amidoxime derivatives, intermediate products and method for their production and use as fungicides | CBR3, CBR1, CYP1B1 | NR3C1 1218/4885GPR35 3455/4885HTR2A 2326/4885 |
| US-20030120085-A1 | Novel benzamidoxime derivatives, intermediates and processes for their preparation, and their use as fungicides | CBR1, CBR3, CYP1B1 | NR3C1 1861/4885GPR35 3061/4885HTR2A 3815/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.