Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 11/20 | 0.38 |
| ▸ | TRPA1 | O75762 | 3/20 | 0.35 |
| ▸ | AR | P10275 | 1/20 | 0.34 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.34 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5887436 | 0.81 | CYP2A6 (0.36) | HSD11B1 | |
| SCHEMBL6047589 | 0.77 | PTGS1 (0.35) | — | |
| SCHEMBL1047574 | 0.74 | HSD11B1 (0.52) | HSD11B1TRPA1ARTRPM8 | |
| SCHEMBL6047588 | 0.73 | NPBWR1 (0.38) | HSD11B1 | |
| SCHEMBL28922699 | 0.72 | HSD11B1 (0.50) | HSD11B1TRPA1ARTRPM8 | |
| SCHEMBL5887404 | 0.71 | L3MBTL1 (0.40) | — | |
| SCHEMBL6047653 | 0.71 | HSD11B1 (0.37) | HSD11B1 | |
| SCHEMBL5887582 | 0.64 | TSHR (0.43) | — | |
| SCHEMBL22304414 | 0.64 | AR (0.58) | HSD11B1TRPA1ARTRPM8 | |
| SCHEMBL24297565 | 0.62 | AR (0.56) | HSD11B1TRPA1ARTRPM8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2006501194-A | — | — | 2006-01-12 | — | — | JP | claimed |
| EP-1525190-A1 | CCK-1 RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2005-04-27 | — | — | EP | claimed |
| WO-2004007463-A1 | CCK-1 RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA, N.V. (BE) | 2004-01-22 | — | — | WO | claimed |