Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 6/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.48 |
| ▸ | HTR2A | P28223 | 1/20 | 0.48 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4397330 | 0.85 | TSHR (0.61) | TSHRSMN1; SMN2ALDH1A1HSD17B10NPSR1 | |
| SCHEMBL538560 | 0.85 | SMN1; SMN2 (0.68) | TSHRSMN1; SMN2ALDH1A1HSD17B10NPSR1 | |
| SCHEMBL27831715 | 0.84 | TSHR (0.59) | TSHRSMN1; SMN2ALDH1A1HSD17B10NPSR1 | |
| SCHEMBL10953526 | 0.83 | TSHR (0.57) | TSHRSMN1; SMN2ALDH1A1SLC6A4HSD17B10 | |
| SCHEMBL28160008 | 0.83 | ALDH1A1 (0.58) | TSHRSMN1; SMN2ALDH1A1HSD17B10NPSR1 | |
| SCHEMBL11424711 | 0.83 | TSHR (0.57) | TSHRSMN1; SMN2ALDH1A1HSD17B10NPSR1 | |
| SCHEMBL28974979 | 0.82 | TSHR (0.74) | TSHRSMN1; SMN2ALDH1A1HSD17B10MAPT | |
| SCHEMBL6049187 | 0.81 | HTT (0.54) | TSHRSMN1; SMN2ALDH1A1HTR2ASLC6A4 | |
| SCHEMBL18979007 | 0.81 | SMN1; SMN2 (0.55) | TSHRSMN1; SMN2ALDH1A1HSD17B10NPSR1 | |
| SCHEMBL27254978 | 0.80 | TSHR (0.57) | TSHRSMN1; SMN2ALDH1A1HSD17B10NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1184372-B1 | Phenoxyphenylheterocycle derivatives as selective serotonin reuptake inhibitors (SSRIs) | PFIZER LTD (GB) | 2006-04-26 | — | — | EP | disclosed |
| US-6630504-B2 | Activity as selective serotonin re- uptake inhibitors (SSRIs); for therapy and prophylaxis of depression, attention deficit hyperactivity disorder, obsessive-compulsive disorder, post-traumatic stress disorder, sexual dysfunction | PFIZER INC. | 2003-10-07 | — | — | US | disclosed |
| US-20020183303-A1 | Phenoxyphenylheterocyclyl derivatives as SSRIs | PFIZER INC. | 2002-12-05 | — | — | US | disclosed |
| EP-1184372-A1 | Phenoxyphenylheterocycle derivatives as selective serotonin reuptake inhibitors (SSRIs) | Pfizer Limited (GB) | 2002-03-06 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020183303-A1 | Phenoxyphenylheterocyclyl derivatives as SSRIs | CRHR1, NR3C1, HTR6 | TSHR 188/4885SMN1; SMN2 3041/4885ALDH1A1 1006/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.