SCHEMBL606274

SCHEMBL606274

Cc1ccc(Nc2cccc(-c3cc(C(C)C)ccc3-c3ccccc3)c2)c(C)c1

nearest known ligand 0.40

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
MAPT P10636 6/20 0.40
SMN1; SMN2 Q16637 5/20 0.39
LMNA P02545 4/20 0.39
MAPK1 P28482 4/20 0.39
ALDH1A1 P00352 3/20 0.39
ALOX12 P18054 2/20 0.39
TDP1 Q9NUW8 2/20 0.39
HPGD P15428 1/20 0.39
L3MBTL1 Q9Y468 1/20 0.39
RAB9A P51151 1/20 0.38
JAK2 O60674 1/20 0.38
GAA P10253 3/20 0.37
NPSR1 Q6W5P4 2/20 0.37
RAPGEF4 Q8WZA2 1/20 0.36
HTT P42858 2/20 0.36
MEN1 O00255 3/20 0.34
KMT2A Q03164 3/20 0.34
AKR1C3 P42330 1/20 0.34
AKR1C2 P52895 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL606273 0.88 MAPT (0.45) MAPTSMN1; SMN2LMNAMAPK1ALDH1A1
SCHEMBL2150100 0.82 RAPGEF4 (0.46) MAPTSMN1; SMN2LMNAMAPK1ALDH1A1
SCHEMBL10878363 0.74 LMNA (0.54) MAPTSMN1; SMN2LMNAHPGDMEN1
SCHEMBL29473561 0.72 GAA (0.62) MAPTSMN1; SMN2LMNAMAPK1TDP1
SCHEMBL429859 0.72 GAA (0.62) MAPTSMN1; SMN2LMNAMAPK1TDP1
SCHEMBL23446824 0.71 KCNK18 (0.39) MAPTSMN1; SMN2LMNAALDH1A1L3MBTL1
SCHEMBL8823290 0.71 METAP2 (0.43) MAPTSMN1; SMN2LMNAHPGDNPSR1
SCHEMBL5608725 0.71 NPSR1 (0.59) MAPTSMN1; SMN2RAB9AGAANPSR1
SCHEMBL9177210 0.71 LMNA (0.50) MAPTLMNAHPGDMEN1KMT2A
SCHEMBL24174910 0.70 NPSR1 (0.59) MAPTSMN1; SMN2LMNAMAPK1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9577199-B2 Deuterated compounds for electronic applications E I DU PONT NEMOURS AND COMPANY (US) 2017-02-21 US disclosed
US-9260657-B2 Chrysene compounds for luminescent applications E I DU PONT DE NEMOURS AND COMPANY (US) 2016-02-16 US disclosed
EP-2671936-B1 Chrysene compounds for luminescent applications DU PONT (US) 2015-06-24 EP disclosed
EP-2432849-B1 CHRYSENE COMPOUNDS FOR LUMINESCENT APPLICATIONS DU PONT (US) 2015-02-25 EP disclosed
US-20150021586-A1 DEUTERATED COMPOUNDS FOR ELECTRONIC APPLICATIONS LG CHEM, LTD. (KR) 2015-01-22 US disclosed
US-8890131-B2 Deuterated compounds for electronic applications E I DU PONT DE NEMOURS AND COMPANY (US) 2014-11-18 US disclosed
US-8759818-B2 Deuterated compounds for electronic applications E I DU PONT DE NEMOURS AND COMPANY (US) 2014-06-24 US disclosed
EP-2674469-A1 Chrysene compounds for luminescent applications E. I. du Pont de Nemours and Company (US) 2013-12-18 EP disclosed
EP-2671936-A1 Chrysene compounds for luminescent applications E. I. du Pont de Nemours and Company (US) 2013-12-11 EP disclosed
EP-2669351-A1 Chrysene compounds for luminescent applications E. I. du Pont de Nemours and Company (US) 2013-12-04 EP disclosed
US-20120037898-A1 CHRYSENE COMPOUNDS FOR LUMINESCENT APPLICATIONS E.I. DU PONT DE NEMOURS AND COMPANY (US) 2012-02-16 US disclosed
US-20110215715-A1 CHRYSENE COMPOUNDS FOR BLUE OR GREEN LUMINESCENT APPLICATIONS E.I. DU PONT DE NEMOURS AND COMPANY (US) 2011-09-08 US disclosed
EP-2350230-A2 CHRYSENE COMPOUNDS FOR BLUE OR GREEN LUMINESCENT APPLICATIONS E. I. du Pont de Nemours and Company (US) 2011-08-03 EP disclosed
WO-2011087815-A2 DEUTERATED ZIRCONIUM COMPOUND FOR ELECTRONIC APPLICATIONS E. I. DU PONT DE NEMOURS AND COMPANY (US) 2011-07-21 WO disclosed
US-20110148287-A1 DEUTERATED ZIRCONIUM COMPOUND FOR ELECTRONIC APPLICATIONS E. I. DU PONT DE NEMOURS AND COMPANY (US) 2011-06-23 US disclosed
WO-2011071507-A1 DEUTERATED COMPOUND AS PART OF A COMBINATION OF COMPOUNDS FOR ELECTRONIC APPLICATIONS E. I. DU PONT DE NEMOURS AND COMPANY (US) 2011-06-16 WO disclosed
US-20110133632-A1 DEUTERATED COMPOUND AS PART OF A COMBINATION OF COMPOUNDS FOR ELECTRONIC APPLICATIONS E.I. DU PONT DE NEMOURS AND COMPANY (US) 2011-06-09 US disclosed
WO-2011028216-A1 DEUTERATED COMPOUNDS FOR ELECTRONIC APPLICATIONS E. I. DU PONT DE NEMOURS AND COMPANY (US) 2011-03-10 WO disclosed
US-20110037057-A1 DEUTERATED COMPOUNDS FOR ELECTRONIC APPLICATIONS E.I. DU PONT DE NEMOURS AND COMPANY (US) 2011-02-17 US disclosed
WO-2010059837-A2 CHRYSENE COMPOUNDS FOR BLUE OR GREEN LUMINESCENT APPLICATIONS E. I. DU PONT DE NEMOURS AND COMPANY (US) 2010-05-27 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110215715-A1 CHRYSENE COMPOUNDS FOR BLUE OR GREEN LUMINESCENT APPLICATIONS CRY2, CRY1, CYBA MAPT 1206/4885SMN1; SMN2 4587/4885LMNA 282/4885
US-20120037898-A1 CHRYSENE COMPOUNDS FOR LUMINESCENT APPLICATIONS CRY2, CENPE, CRY1 MAPT 1308/4885SMN1; SMN2 4138/4885LMNA 511/4885
US-20110148287-A1 DEUTERATED ZIRCONIUM COMPOUND FOR ELECTRONIC APPLICATIONS SLC39A3, SLC39A11, EED MAPT 2542/4885SMN1; SMN2 3669/4885LMNA 3720/4885
US-20110037057-A1 DEUTERATED COMPOUNDS FOR ELECTRONIC APPLICATIONS DDT, AHR, EED MAPT 3496/4885SMN1; SMN2 3130/4885LMNA 1933/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.