SCHEMBL6062883

SCHEMBL6062883

CC[C](CCc1ccccc1)c1ccccc1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 1/20 0.50
KEAP1 Q14145 1/20 0.48
TDP1 Q9NUW8 4/20 0.46
NPC1 O15118 2/20 0.46
RAB9A P51151 2/20 0.46
CASP3 P42574 1/20 0.46
SENP8 Q96LD8 1/20 0.46
SENP7 Q9BQF6 1/20 0.46
SENP6 Q9GZR1 1/20 0.46
FFAR1 O14842 1/20 0.45
GRIN1 Q05586 1/20 0.44
GRIN2B Q13224 1/20 0.44
KDM4E B2RXH2 1/20 0.44
HDAC2 Q92769 2/20 0.42
HDAC8 Q9BY41 2/20 0.42
HDAC6 Q9UBN7 2/20 0.42
ATM Q13315 1/20 0.42
KMT2A Q03164 1/20 0.42
HPGD P15428 1/20 0.41
CTSL P07711 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL814927 0.80 CES2 (0.52) ATMKMT2AHPGDTP53SMN1; SMN2
SCHEMBL451258 0.79 ATM (0.54) ALDH1A1TDP1RAB9AKDM4EATM
SCHEMBL628981 0.78 ATM (0.45) ALDH1A1HDAC8HDAC6ATMKMT2A
SCHEMBL815083 0.77 PTGS2 (0.57) ALDH1A1ATMCES2CES1
SCHEMBL9427231 0.76 ALDH1A1 (0.56) ALDH1A1KEAP1TDP1NPC1RAB9A
SCHEMBL815888 0.75 CES2 (0.56) CES2CES1
SCHEMBL155800 0.75 TDP1 (0.55) TDP1NPC1RAB9ACASP3SENP8
SCHEMBL1305408 0.74 ALDH1A1 (0.59) ALDH1A1KEAP1TDP1NPC1RAB9A
SCHEMBL4222999 0.74 ALDH1A1 (0.59) ALDH1A1KEAP1TDP1FFAR1GRIN1
SCHEMBL814748 0.73 CES2 (0.58) TDP1KMT2ACES2CES1L3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3389720-A1 POLYACETAL POLYMERS, CONJUGATES, PARTICLES AND USES THEREOF The General Hospital Corporation (US) 2018-10-24 EP disclosed
WO-2017106630-A1 POLYACETAL POLYMERS, CONJUGATES, PARTICLES AND USES THEREOF THE GENERAL HOSPITAL CORPORATION (US) 2017-06-22 WO disclosed
EP-2978785-A1 PMMA PROVIDED WITH IMPACT RESISTANCE AND HAVING IMPROVED OPTICAL PROPERTIES Evonik Röhm GmbH (DE) 2016-02-03 EP disclosed
WO-2014154543-A1 PMMA PROVIDED WITH IMPACT RESISTANCE AND HAVING IMPROVED OPTICAL PROPERTIES EVONIK RÖHM GMBH (DE) 2014-10-02 WO disclosed
US-20140141230-A1 PERMANENT ATTACHMENT OF AMMONIUM AND GUANIDINE-BASED ANTIMICROBIALS TO SURFACES CONTAINING C-H FUNCTIONALITY UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. 2014-05-22 US disclosed
US-20140134906-A1 PERMANENT ATTACHMENT OF PIGMENTS AND DYES TO SURFACES CONTAINING CALKYL-OH FUNCTIONALITY UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. 2014-05-15 US disclosed
US-20140134107-A1 COMPOUNDS, PROBES, AND METHODS OF SYNTHESIS AND METHODS OF IMAGING COX-2-ASSOCIATED DISEASES VANDERBILT UNIVERSITY 2014-05-15 US disclosed
US-20140121333-A1 PERMANENT ATTACHMENT OF AGENTS TO SURFACES CONTAINING C-H FUNCTIONALITY UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. 2014-05-01 US disclosed
EP-1694357-A1 USE OF CATHEPSIN S INHIBITORS FOR TREATING AN IMMUNE RESPONSE CAUSED BY ADMINISTRATION OF A SMALL MOLECULE THERAPEUTIC OR BIOLOGIC AXYS PHARMACEUTICALS, INC. (US) 2006-08-30 EP disclosed
WO-2005058348-A1 USE OF CATHEPSIN S INHIBITORS FOR TREATING AN IMMUNE RESPONSE CAUSED BY ADMINISTRATION OF A SMALL MOLECULE THERAPEUTIC OR BIOLOGIC AXYS PHARMACEUTICALS, INC. (US) 2005-06-30 WO disclosed
EP-1261611-A2 INHIBITORS OF HEPATITIS C VIRUS NS3 PROTEASE Bristol-Myers Squibb Pharma Company (US) 2002-12-04 EP disclosed
WO-2001077102-A1 MACROCYCLIC CHELANTS FOR METALLOPHARMACEUTICALS BRISTOL-MYERS SQUIBB PHARMA COMPANY (US) 2001-10-18 WO disclosed
WO-2001064678-A2 INHIBITORS OF HEPATITIS C VIRUS NS3 PROTEASE BRISTOL-MYERS SQUIBB PHARMA COMPANY (US) 2001-09-07 WO disclosed
US-5508273-A ARALKYLPHOSPHONATES FOR OSTEOPOROSIS ORTHO PHARMACEUTICAL CORPORATION (US) 1996-04-16 US disclosed
US-5300646-A Intermediates for acylcoenzyme A:cholesterol acyltransferase inhibitors TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1994-04-05 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140141230-A1 PERMANENT ATTACHMENT OF AMMONIUM AND GUANIDINE-BASED ANTIMICROBIALS TO SURFACES CONTAINING C-H FUNCTIONALITY GMPS, ARG1, ALKBH1 ALDH1A1 1320/4885KEAP1 3465/4885TDP1 1568/4885
US-20140134107-A1 COMPOUNDS, PROBES, AND METHODS OF SYNTHESIS AND METHODS OF IMAGING COX-2-ASSOCIATED DISEASES PTGS2, PTGES2, PTGES ALDH1A1 1170/4885KEAP1 594/4885TDP1 2221/4885
US-20140134906-A1 PERMANENT ATTACHMENT OF PIGMENTS AND DYES TO SURFACES CONTAINING CALKYL-OH FUNCTIONALITY TYR, ALDH1A2, CALD1 ALDH1A1 115/4885KEAP1 540/4885TDP1 2462/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.