SCHEMBL60737

SCHEMBL60737

COc1ccc(C(c2ccccc2)(c2ccc(OC)cc2)C(O)[C@H]2O[C@@H](n3cc(C)c(=O)[nH]c3=O)C[C@@H]2O)cc1

nearest known ligand 0.52

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
TK1 P04183 5/20 0.52
TYMS P04818 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9564565 1.00 TK1 (0.52) TK1TYMS
SCHEMBL7535867 1.00 TK1 (0.52) TK1TYMS
SCHEMBL4626081 0.93 TK1 (0.55) TK1
SCHEMBL5086844 0.90 TK1 (0.47) TK1TYMS
SCHEMBL5486404 0.90 LMNA (0.47) TK1TYMS
SCHEMBL8426287 0.90 TK1 (0.45) TK1TYMS
SCHEMBL8999406 0.90 TK1 (0.45) TK1
SCHEMBL1501551 0.90 TYMS (0.44) TK1TYMS
SCHEMBL2027058 0.89 LMNA (0.50) TK1TYMS
SCHEMBL8892073 0.89 TYMS (0.43) TK1TYMS

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 165 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3221330-B1 PHOSPHORAMIDITE SYNTHONES FOR THE SYNTHESIS OF SELF-NEUTRALIZING OLIGONUCLEOTIDE COMPOUNDS ZATA PHARMACEUTICALS INC (US) 2026-04-22 EP disclosed
US-12559517-B2 Oligonucleotide manufacturing method AJINOMOTO CO., INC. (JP) 2026-02-24 US disclosed
US-20230193258-A1 METHODS AND COMPOSITIONS FOR THE TREATMENT OF CANCER OR OTHER DISEASES CITY OF HOPE 2023-06-22 US disclosed
US-11566042-B2 Phosphoramidite synthones for the synthesis of self-neutralizing oligonucleotide compounds ZATA Pharmaceuticals, Inc (US) 2023-01-31 US disclosed
US-20220235090-A1 OLIGONUCLEOTIDE MANUFACTURING METHOD AJINOMOTO CO., INC. (JP) 2022-07-28 US disclosed
US-20220127300-A1 5'-MODIFIED NUCLEOSIDE AND NUCLEOTIDE USING SAME OSAKA UNIVERSITY (JP) 2022-04-28 US disclosed
US-20200354397-A1 PHOSPHORAMIDITE SYNTHONES FOR THE SYNTHESIS OF SELF-NEUTRALIZING OLIGONUCLEOTIDE COMPOUNDS ZATA PHARMACEUTICALS INC (US) 2020-11-12 US disclosed
US-10723755-B2 Phosphoramidite synthones for the synthesis of self-neutralizing oligonucleotide compounds ZATA PHARMACEUTICALS, INC. (US) 2020-07-28 US disclosed
US-10378051-B2 Continuous extension and deblocking in reactions for nucleic acids synthesis and sequencing ILLUMINA CAMBRIDGE LIMITED (GB) 2019-08-13 US disclosed
US-20180291056-A1 OLIGONUCLEOTIDE MANUFACTURING METHOD AJINOMOTO CO., INC. (JP) 2018-10-11 US disclosed
US-4552922-A POLYMERIC SUPPORTS CARRYING REACTIVE SPECIES; INTERMEDIATE REMOVESONE SPECIES AND CARRIES IT TO SECOND; TWO SPECIES REACT RELEASING INTERMEDIATE YEDA RESEARCH & DEVELOPMENT CO. LTD. (IL) 1985-11-12 US disclosed
EP-0155950-A1 OLIGONUCLEOTIDE POLYMERIC SUPPORT SYSTEM. MOLECULAR BIOSYSTEMS INC (US) 1985-10-02 EP disclosed
WO-1985002628-A1 NUCLEIC ACID HYBRIDIZATION ASSAY HRI RESEARCH, INC. (US) 1985-06-20 WO disclosed
WO-1985001051-A1 OLIGONUCLEOTIDE POLYMERIC SUPPORT SYSTEM MOLECULAR BIOSYSTEMS, INC. (US) 1985-03-14 WO disclosed
EP-0115613-A2 DNA sequences, their preparation, plasmids containing these sequences and their use in the synthesis of eukaryotic gene products in prokaryotes BOEHRINGER INGELHEIM INTERNATIONAL GmbH (DE) 1984-08-15 EP disclosed
EP-0108387-A1 Preparation of recombinant growth releasing factors F. HOFFMANN-LA ROCHE AG (CH) 1984-05-16 EP disclosed
EP-0106434-A1 Method and apparatus for multipolymer synthesis systems YEDA RESEARCH AND DEVELOPMENT COMPANY, LTD. (IL) 1984-04-25 EP disclosed
US-4433140-A Tridecadeoxynucleotide, process for preparation thereof, and use thereof DR. KARL THOMAE GMBH (DE) 1984-02-21 US disclosed
EP-0083777-A1 Physiologically active peptide with between 147 and 162 amino acid residues Asahi Kasei Kogyo Kabushiki Kaisha (JP) 1983-07-20 EP disclosed
EP-0058954-A2 Tridecadeoxynucleotide, process for its preparation and the application Dr. Karl Thomae GmbH (DE) 1982-09-01 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11566042-B2 Phosphoramidite synthones for the synthesis of self-neutralizing oligonucleotide compounds PNKP, POLI, TYMP TK1 55/4885TYMS 7/4885
US-20220235090-A1 OLIGONUCLEOTIDE MANUFACTURING METHOD RNGTT, IGF2BP2, DCLRE1B TK1 110/4885TYMS 37/4885
US-20180291056-A1 OLIGONUCLEOTIDE MANUFACTURING METHOD RNGTT, IGF2BP2, DCLRE1B TK1 110/4885TYMS 37/4885
US-20230193258-A1 METHODS AND COMPOSITIONS FOR THE TREATMENT OF CANCER OR OTHER DISEASES HLA-DRB1, CD47, IL2 TK1 1889/4885TYMS 996/4885
US-12559517-B2 Oligonucleotide manufacturing method POLL, IGF2BP1, POLI TK1 48/4885TYMS 363/4885
US-10723755-B2 Phosphoramidite synthones for the synthesis of self-neutralizing oligonucleotide compounds PNKP, POLI, TYMP TK1 83/4885TYMS 10/4885
US-20200354397-A1 PHOSPHORAMIDITE SYNTHONES FOR THE SYNTHESIS OF SELF-NEUTRALIZING OLIGONUCLEOTIDE COMPOUNDS PNKP, POLI, TYMP TK1 55/4885TYMS 7/4885
US-20220127300-A1 5'-MODIFIED NUCLEOSIDE AND NUCLEOTIDE USING SAME NT5C3B, DUT, RNGTT TK1 99/4885TYMS 54/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.