Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.64 |
| ▸ | LMNA | P02545 | 4/20 | 0.64 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.64 |
| ▸ | TSHR | P16473 | 1/20 | 0.64 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | RECQL | P46063 | 1/20 | 0.49 |
| ▸ | GHSR | Q92847 | 3/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | IDH1 | O75874 | 1/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6078353 | 0.83 | CYP26A1 (0.57) | ALDH1A1LMNAKDM4EMEN1KMT2A | |
| SCHEMBL11455802 | 0.79 | ALDH1A1 (0.73) | ALDH1A1LMNAHSD17B10KDM4ETSHR | |
| SCHEMBL9224876 | 0.77 | LMNA (0.70) | ALDH1A1LMNAHSD17B10KDM4ETSHR | |
| SCHEMBL6079320 | 0.76 | PLAU (0.73) | ALDH1A1LMNAKDM4ETSHRMEN1 | |
| SCHEMBL5842450 | 0.75 | HPGD (0.63) | ALDH1A1LMNAHSD17B10KDM4ETSHR | |
| SCHEMBL6079658 | 0.74 | GAA (0.62) | ALDH1A1LMNAHSD17B10MEN1KMT2A | |
| SCHEMBL5153509 | 0.73 | USP2 (0.61) | ALDH1A1LMNAHSD17B10KDM4ETSHR | |
| SCHEMBL13742498 | 0.73 | PGR (0.53) | ALDH1A1LMNAHSD17B10KDM4ETSHR | |
| SCHEMBL7791354 | 0.73 | PLAU (0.72) | ALDH1A1LMNAHSD17B10KDM4ETSHR | |
| SCHEMBL6078852 | 0.73 | ENPP2 (0.58) | ALDH1A1LMNAMEN1KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7071231-B2 | Naphthalene ureas as glucose uptake enhancers | TELIK, INC. (US) | 2006-07-04 | — | — | US | disclosed |
| EP-1181271-B1 | NAPHTHALENE UREAS AS GLUCOSE UPTAKE ENHANCERS | TELIK INC (US) | 2005-01-19 | — | — | EP | disclosed |
| US-6458998-B1 | NAPHTHALENEUREAS AS ANTIDIABETIC AGENTS | TELIK, INC. | 2002-10-01 | — | — | US | disclosed |