Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C4 | P17516 | 4/20 | 0.68 |
| ▸ | AKR1C3 | P42330 | 4/20 | 0.68 |
| ▸ | AKR1C2 | P52895 | 4/20 | 0.68 |
| ▸ | AKR1C1 | Q04828 | 4/20 | 0.68 |
| ▸ | MEN1 | O00255 | 7/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.67 |
| ▸ | PKM | P14618 | 2/20 | 0.67 |
| ▸ | MAPT | P10636 | 4/20 | 0.63 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.63 |
| ▸ | ABL1 | P00519 | 1/20 | 0.63 |
| ▸ | TSHR | P16473 | 1/20 | 0.63 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.63 |
| ▸ | GRIK1 | P39086 | 2/20 | 0.57 |
| ▸ | GFER | P55789 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
| ▸ | CA12 | O43570 | 1/20 | 0.53 |
| ▸ | CA1 | P00915 | 1/20 | 0.53 |
| ▸ | CA2 | P00918 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL637477 | 0.90 | KMT2A (0.70) | AKR1C4AKR1C3AKR1C2AKR1C1MEN1 | |
| SCHEMBL6091063 | 0.89 | MEN1 (0.84) | AKR1C4AKR1C3AKR1C2AKR1C1MEN1 | |
| SCHEMBL6091702 | 0.89 | MEN1 (0.78) | AKR1C4AKR1C3AKR1C2AKR1C1MEN1 | |
| SCHEMBL2272270 | 0.87 | SUCNR1 (0.67) | AKR1C4AKR1C3AKR1C2AKR1C1MEN1 | |
| SCHEMBL4669087 | 0.85 | MEN1 (0.65) | AKR1C4AKR1C3AKR1C2AKR1C1MEN1 | |
| SCHEMBL2275060 | 0.84 | AKR1C4 (0.59) | AKR1C4AKR1C3AKR1C2AKR1C1MEN1 | |
| SCHEMBL9973845 | 0.83 | TOP1 (0.59) | AKR1C4AKR1C3AKR1C2AKR1C1MEN1 | |
| SCHEMBL2271193 | 0.82 | ACLY (0.64) | AKR1C4AKR1C3AKR1C2AKR1C1MEN1 | |
| SCHEMBL9973843 | 0.81 | TOP1 (0.58) | MEN1KMT2APKMMAPTTDP1 | |
| SCHEMBL6350875 | 0.81 | AKR1C2 (1.00) | AKR1C4AKR1C3AKR1C2AKR1C1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230129036-A1 | AVENANTHRAMIDE COMPOSITIONS WITH IMPROVED SOLUBILITY COMPRISING 4-HYDROXYPHENONE | SYMRISE AG (DE) | 2023-04-27 | — | — | US | disclosed |
| US-20230129036-A1 | AVENANTHRAMIDE COMPOSITIONS WITH IMPROVED SOLUBILITY COMPRISING 4-HYDROXYPHENONE | SYMRISE AG (DE) | 2023-04-27 | — | — | US | disclosed |
| US-20230131993-A1 | COMPOSITION COMPRISING AN AVENANTHRAMIDE OR AN ANALOGUE THEREOF WITH IMPROVED STABILITY | SYMRISE AG (DE) | 2023-04-27 | — | — | US | disclosed |
| US-20230131993-A1 | COMPOSITION COMPRISING AN AVENANTHRAMIDE OR AN ANALOGUE THEREOF WITH IMPROVED STABILITY | SYMRISE AG (DE) | 2023-04-27 | — | — | US | disclosed |
| US-20230118467-A1 | COSMETIC OR PHARMACEUTICAL USE OF AVENANTHRAMIDE L | SYMRISE AG (DE) | 2023-04-20 | — | — | US | disclosed |
| US-8911795-B2 | Compositions comprising dihydroavenanthramide D and climbazole as cosmetic and pharmaceutical compositions for alleviating itching | SYMRISE AG (DE) | 2014-12-16 | — | — | US | disclosed |
| US-8911795-B2 | Compositions comprising dihydroavenanthramide D and climbazole as cosmetic and pharmaceutical compositions for alleviating itching | SYMRISE AG (DE) | 2014-12-16 | — | — | US | disclosed |
| US-8409552-B2 | Anthranillic acid amides and derivatives thereof as cosmetic and pharmaceutical active compounds | SYMRISE AG (DE) | 2013-04-02 | — | — | US | disclosed |
| US-8409552-B2 | Anthranillic acid amides and derivatives thereof as cosmetic and pharmaceutical active compounds | SYMRISE AG (DE) | 2013-04-02 | — | — | US | disclosed |
| US-8409552-B2 | Anthranillic acid amides and derivatives thereof as cosmetic and pharmaceutical active compounds | SYMRISE AG (DE) | 2013-04-02 | — | — | US | disclosed |
| US-8203016-B2 | Anthranilic acid amides and derivatives thereof as cosmetic and pharmaceutical agents | SYMRISE AG (DE) | 2012-06-19 | — | — | US | disclosed |
| US-20090297468-A1 | Mixtures Comprising Anthranilic Acid Amides and Cooling Agents as Cosmetic and Pharmaceutical Compositions for Alleviating Itching | SYMRISE GMBH & CO. KG (DE) | 2009-12-03 | — | — | US | disclosed |
| US-20090297468-A1 | Mixtures Comprising Anthranilic Acid Amides and Cooling Agents as Cosmetic and Pharmaceutical Compositions for Alleviating Itching | SYMRISE GMBH & CO. KG (DE) | 2009-12-03 | — | — | US | disclosed |
| US-20090226537-A1 | MIXTURES COMPRISING ANTHRANILIC ACID AMIDES AND ANTIDANDRUFF AGENTS AS COSMETIC AND PHARMACEUTICAL COMPOSITIONS FOR ALLEVIATING ITCHING | SYMRISE GMBH & CO. KG (DE) | 2009-09-10 | — | — | US | disclosed |
| US-20090226537-A1 | MIXTURES COMPRISING ANTHRANILIC ACID AMIDES AND ANTIDANDRUFF AGENTS AS COSMETIC AND PHARMACEUTICAL COMPOSITIONS FOR ALLEVIATING ITCHING | SYMRISE GMBH & CO. KG (DE) | 2009-09-10 | — | — | US | disclosed |
| EP-1886662-A1 | Anti-microbial compounds for treating bad breath | Symrise GmbH & Co. KG (DE) | 2008-02-13 | — | — | EP | disclosed |
| US-20080008660-A1 | Antimicrobially active compounds for treating bad breath | SYMRISE GMBH & CO. KG (DE) | 2008-01-10 | — | — | US | disclosed |
| US-20080008660-A1 | Antimicrobially active compounds for treating bad breath | SYMRISE GMBH & CO. KG (DE) | 2008-01-10 | — | — | US | disclosed |
| WO-2007062957-A1 | MIXTURES COMPRISING ANTHRANILIC ACID AMIDES AND ANTIDANDRUFF AGENTS AS COSMETIC AND PHARMACEUTICAL COMPOSITIONS FOR ALLEVIATING ITCHING | SYMRISE GMBH & CO. KG (DE) | 2007-06-07 | — | — | WO | disclosed |
| US-20060089413-A1 | Anthranilic acid amides and derivatives thereof as cosmetic and pharmaceutical agents | SYMRISE GMBH & CO. KG (DE) | 2006-04-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060089413-A1 | Anthranilic acid amides and derivatives thereof as cosmetic and pharmaceutical agents | HRH1, CMA1, HRH2 | AKR1C4 1811/4885AKR1C3 1567/4885AKR1C2 1447/4885 |
| US-20090297468-A1 | Mixtures Comprising Anthranilic Acid Amides and Cooling Agents as Cosmetic and Pharmaceutical Compositions for Alleviating Itching | H1-0, ASIC1, MCOLN1 | AKR1C4 420/4885AKR1C3 194/4885AKR1C2 351/4885 |
| US-20230129036-A1 | AVENANTHRAMIDE COMPOSITIONS WITH IMPROVED SOLUBILITY COMPRISING 4-HYDROXYPHENONE | HPD, CYP4A22, PAH | AKR1C4 96/4885AKR1C3 177/4885AKR1C2 105/4885 |
| US-20090226537-A1 | MIXTURES COMPRISING ANTHRANILIC ACID AMIDES AND ANTIDANDRUFF AGENTS AS COSMETIC AND PHARMACEUTICAL COMPOSITIONS FOR ALLEVIATING ITCHING | H1-0, ASIC1, NHERF1 | AKR1C4 531/4885AKR1C3 268/4885AKR1C2 454/4885 |
| US-20230131993-A1 | COMPOSITION COMPRISING AN AVENANTHRAMIDE OR AN ANALOGUE THEREOF WITH IMPROVED STABILITY | OAT, PIGS, HLA-A | AKR1C4 1078/4885AKR1C3 1591/4885AKR1C2 946/4885 |
| US-20080008660-A1 | Antimicrobially active compounds for treating bad breath | CAT, LPO, GPX1 | AKR1C4 756/4885AKR1C3 729/4885AKR1C2 791/4885 |
| US-20230118467-A1 | COSMETIC OR PHARMACEUTICAL USE OF AVENANTHRAMIDE L | TACR1, NPSR1, TACR2 | AKR1C4 143/4885AKR1C3 108/4885AKR1C2 78/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.