Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 10/20 | 0.56 |
| ▸ | MMP13 | P45452 | 7/20 | 0.56 |
| ▸ | MMP12 | P39900 | 1/20 | 0.48 |
| ▸ | FPR2 | P25090 | 1/20 | 0.48 |
| ▸ | PROKR1 | Q8TCW9 | 1/20 | 0.48 |
| ▸ | LIPE | Q05469 | 1/20 | 0.46 |
| ▸ | MMP9 | P14780 | 4/20 | 0.44 |
| ▸ | TEAD1 | P28347 | 1/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.43 |
| ▸ | ACACB | O00763 | 1/20 | 0.43 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6097719 | 0.89 | MMP13 (0.52) | MMP2MMP13MMP12FPR2PROKR1 | |
| SCHEMBL6112364 | 0.89 | MMP13 (0.51) | MMP2MMP13MMP12FPR2PROKR1 | |
| SCHEMBL6096945 | 0.83 | MMP13 (0.43) | MMP2MMP13MMP12FPR2PROKR1 | |
| SCHEMBL6098249 | 0.79 | FPR2 (0.56) | MMP2MMP13MMP12FPR2PROKR1 | |
| SCHEMBL6098206 | 0.78 | MMP13 (0.60) | MMP2MMP13MMP12FPR2PROKR1 | |
| SCHEMBL5717406 | 0.76 | MMP2 (0.44) | MMP2MMP13MMP9LMNA | |
| SCHEMBL7395651 | 0.75 | MMP13 (0.53) | MMP2MMP13MMP12FPR2PROKR1 | |
| SCHEMBL6096681 | 0.75 | FPR2 (0.61) | MMP2MMP13MMP12FPR2PROKR1 | |
| SCHEMBL5898947 | 0.75 | MMP13 (0.70) | MMP2MMP13MMP12FPR2PROKR1 | |
| SCHEMBL7398293 | 0.74 | MMP13 (0.55) | MMP2MMP13MMP12FPR2PROKR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7067670-B2 | Sulfamato hydroxamic acid metalloprotease inhibitor | WARNER LAMBERT COMPANY (US) | 2006-06-27 | — | — | US | disclosed |
| US-20050049280-A1 | Sulfamato hydroxamic acid metalloprotease inhibitor | PHARMACIA CORPORATION | 2005-03-03 | — | — | US | disclosed |
| US-6800646-B1 | Sulfamato hydroxamic acid metalloprotease inhibitor | PHARMACIA CORPORATION | 2004-10-05 | — | — | US | disclosed |
| US-6492367-B1 | Sulfamato hydroxamic acid metalloprotease inhibitor | G. D. SEARLE & COMPANY | 2002-12-10 | — | — | US | disclosed |
| US-6448250-B1 | INHIBITS THE ACTIVITY OF ONE OR MORE OF THE FOLLOWING MATRIX METALLOPROTEINASES: MMP-2, MMP-9, AND MMP-13, WHILE EXHIBITING SUBSTANTIALLY LESS INHIBITORY ACTIVITY AGAINST MMP-1 | G. D. SEARLE & COMPANY | 2002-09-10 | — | — | US | disclosed |
| EP-1157021-A1 | SULFAMATO HYDROXAMIC ACID METALLOPROTEASE INHIBITOR | G.D. SEARLE & CO. (US) | 2001-11-28 | — | — | EP | disclosed |
| WO-2000046221-A1 | SULFAMATO HYDROXAMIC ACID METALLOPROTEASE INHIBITOR | G.D. SEARLE & CO. (US) | 2000-08-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050049280-A1 | Sulfamato hydroxamic acid metalloprotease inhibitor | MMP14, MMP12, MMP17 | MMP2 8/4885MMP13 23/4885MMP12 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.