Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 8/20 | 0.46 |
| ▸ | CA1 | P00915 | 8/20 | 0.46 |
| ▸ | CA2 | P00918 | 8/20 | 0.46 |
| ▸ | CA6 | P23280 | 8/20 | 0.46 |
| ▸ | CA5A | P35218 | 8/20 | 0.46 |
| ▸ | CA7 | P43166 | 8/20 | 0.46 |
| ▸ | CA9 | Q16790 | 8/20 | 0.46 |
| ▸ | CA13 | Q8N1Q1 | 8/20 | 0.46 |
| ▸ | CA14 | Q9ULX7 | 8/20 | 0.46 |
| ▸ | CA5B | Q9Y2D0 | 8/20 | 0.46 |
| ▸ | CA4 | P22748 | 7/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | COMT | P21964 | 1/20 | 0.44 |
| ▸ | CNR1 | P21554 | 1/20 | 0.44 |
| ▸ | CA3 | P07451 | 7/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2415595 | 0.73 | COMT (0.43) | CA12CA1CA2CA6CA5A | |
| SCHEMBL22557425 | 0.69 | CA1 (0.44) | CA12CA1CA2CA6CA5A | |
| SCHEMBL2413125 | 0.68 | HSD11B1 (0.40) | CA12CA1CA2CA6CA5A | |
| SCHEMBL11859802 | 0.68 | L3MBTL1 (0.47) | CA12CA1CA2CA6CA5A | |
| Water SCHEMBL28038773 | 0.67 | COMT (0.35) | CA12CA1CA2CA6CA5A | |
| SCHEMBL16756765 | 0.66 | L3MBTL1 (0.45) | CA12CA1CA2CA6CA5A | |
| SCHEMBL30161536 | 0.66 | TRPV4 (0.47) | CA12CA1CA2CA6CA5A | |
| SCHEMBL534192 | 0.66 | TRPV4 (0.47) | CA12CA1CA2CA6CA5A | |
| SCHEMBL19962939 | 0.66 | MMP2 (0.45) | CA12CA1CA2CA6CA5A | |
| SCHEMBL28039072 | 0.65 | ALDH1A1 (0.51) | L3MBTL1COMTKMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7101892-B2 | Sulfone derivatives as 5-HT7 receptor ligands | MERCK SHARP & DOHME LTD. | 2006-09-05 | — | — | US | disclosed |
| US-20040229864-A1 | Sulfone derivatives as 5-HT7 receptor ligands | MERCK SHARP & DOHME LTD. (GB) | 2004-11-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040229864-A1 | Sulfone derivatives as 5-HT7 receptor ligands | HTR7, HTR2C, HTR1A | CA12 4587/4885CA1 2680/4885CA2 2094/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.