Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.58 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | ERN1 | O75460 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 5/20 | 0.45 |
| ▸ | HTT | P42858 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.45 |
| ▸ | BLM | P54132 | 2/20 | 0.45 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.45 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | CA12 | O43570 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | CA9 | Q16790 | 1/20 | 0.44 |
| ▸ | NCF1 | P14598 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL610757 | 1.00 | MAPT (0.58) | MAPTKDM4EPOLBERN1CYP3A4 | |
| SCHEMBL198641 | 0.76 | MAPT (0.64) | MAPTKDM4EPOLBERN1CYP3A4 | |
| SCHEMBL217044 | 0.75 | MAPT (1.00) | MAPTKDM4EPOLBERN1CYP3A4 | |
| SCHEMBL8384663 | 0.74 | MAPT (0.61) | MAPTKDM4EPOLBERN1CYP3A4 | |
| SCHEMBL3246068 | 0.73 | MAPT (0.58) | MAPTKDM4EPOLBERN1CYP3A4 | |
| SCHEMBL428159 | 0.73 | MAPT (0.58) | MAPTKDM4EPOLBCYP3A4LMNA | |
| SCHEMBL196873 | 0.73 | MAPT (0.58) | MAPTKDM4EPOLBCYP3A4LMNA | |
| SCHEMBL115674 | 0.73 | NCF1 (0.72) | MAPTKDM4EPOLBCYP3A4LMNA | |
| SCHEMBL609118 | 0.73 | MAPT (0.58) | MAPTKDM4EPOLBERN1CYP3A4 | |
| SCHEMBL2907103 | 0.73 | MAPT (0.58) | MAPTKDM4EPOLBERN1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107074878-B | 2, 3-dihydro-thiazolo [3,2-a ] pyridin-5-one derivatives, intermediates thereof and their use as antibacterial agents | 快尔生物技术公司 | 2019-12-24 | — | — | CN | claimed |
| US-10294244-B2 | 2,3-dihydro-thiazolo[3,2-A]pyridin-5-one derivatives, intermediates thereof, and their use as antibacterial agents | QURETECH BIO AB (SE) | 2019-05-21 | — | — | US | claimed |
| US-20170334931-A1 | 2,3-Dihydro-Thiazolo[3,2-A]Pyridin-5-One Derivatives, Intermediates Thereof, and Their Use as Antibacterial Agents | QURETECH BIO AB (SE) | 2017-11-23 | — | — | US | claimed |
| EP-3218382-A1 | 2,3-DIHYDRO-THIAZOLO[3,2-A]PYRIDIN-5-ONE DERIVATIVES, INTERMEDIATES THEREOF, AND THEIR USE AS ANTIBACERIAL AGENTS | Quretech Bio AB (SE) | 2017-09-20 | — | — | EP | claimed |
| WO-2016075296-A1 | 2,3-DIHYDRO-THIAZOLO[3,2-A]PYRIDIN-5-ONE DERIVATIVES, INTERMEDIATES THEREOF, AND THEIR USE AS ANTIBACERIAL AGENTS | QURETECH BIO AB (SE) | 2016-05-19 | — | — | WO | claimed |
| US-8802675-B2 | Neuroprotective multifunctional compounds and pharmaceutical compositions comprising them | TECHNION RESEARCH AND DEVELOPMENT FOUNDATION LTD (IL) | 2014-08-12 | — | — | US | disclosed |
| US-20120040993-A1 | NEUROPROTECTIVE MULTIFUNCTIONAL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | TECHNION RESEARCH AND DEVELOPMENT FOUNDATION LTD. (IL) | 2012-02-16 | — | — | US | disclosed |
| WO-2010086860-A2 | NEUROPROTECTIVE MULTIFUNCTIONAL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | YEDA RESEARCH AND DEVELOPMENT CO. LTD. (IL) | 2010-08-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10294244-B2 | 2,3-dihydro-thiazolo[3,2-A]pyridin-5-one derivatives, intermediates thereof, and their use as antibacterial agents | NOD1, MT-ND1, NDUFB7 | MAPT 1630/4885KDM4E 4412/4885POLB 1935/4885 |
| US-20170334931-A1 | 2,3-Dihydro-Thiazolo[3,2-A]Pyridin-5-One Derivatives, Intermediates Thereof, and Their Use as Antibacterial Agents | NOD1, MT-ND1, NDUFB7 | MAPT 1630/4885KDM4E 4412/4885POLB 1935/4885 |
| US-20120040993-A1 | NEUROPROTECTIVE MULTIFUNCTIONAL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | GSR, GRIN1, GRIN2A | MAPT 1195/4885KDM4E 3218/4885POLB 2564/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.