Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP1 | P29466 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | CTSD | P07339 | 1/20 | 0.34 |
| ▸ | CASP3 | P42574 | 1/20 | 0.34 |
| ▸ | CASP7 | P55210 | 1/20 | 0.34 |
| ▸ | CASP6 | P55212 | 1/20 | 0.34 |
| ▸ | CASP8 | Q14790 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6157558 | 0.83 | KMT2A (0.48) | CASP1KMT2AMAPTALDH1A1 | |
| SCHEMBL6157542 | 0.74 | MTNR1A (0.49) | CASP1MEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL7481736 | 0.74 | KMT2A (0.34) | MEN1KMT2ATP53MAPT | |
| SCHEMBL6161919 | 0.72 | CASP1 (0.47) | CASP1MEN1KMT2ATP53 | |
| SCHEMBL6158570 | 0.72 | CASP1 (0.49) | CASP1MEN1KMT2A | |
| SCHEMBL6157870 | 0.72 | CASP1 (0.56) | CASP1MEN1KMT2A | |
| SCHEMBL7474319 | 0.71 | KMT2A (0.33) | MEN1KMT2A | |
| SCHEMBL6164297 | 0.70 | CASP1 (0.73) | CASP1 | |
| SCHEMBL28629684 | 0.62 | KMT2A (0.65) | MEN1KMT2A | |
| SCHEMBL16281631 | 0.60 | CASP3 (0.33) | CASP1CASP3CASP7CASP6CASP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1082127-B1 | SUCCINAMIDE INHIBITORS OF INTERLEUKIN-1BETA CONVERTING ENZYME | WARNER LAMBERT CO (US) | 2005-06-22 | — | — | EP | claimed |
| EP-1082127-B1 | SUCCINAMIDE INHIBITORS OF INTERLEUKIN-1BETA CONVERTING ENZYME | WARNER LAMBERT CO (US) | 2005-06-22 | — | — | EP | disclosed |