SCHEMBL616449

SCHEMBL616449

CC(=O)c1ccc(Cl)cc1Br

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
FLT1 P17948 2/20 0.50
FLT4 P35916 2/20 0.50
KDR P35968 2/20 0.50
MAOB P27338 4/20 0.46
MAOA P21397 3/20 0.46
SMN1; SMN2 Q16637 2/20 0.45
TSHR P16473 1/20 0.45
CASP1 P29466 1/20 0.45
CA12 O43570 1/20 0.45
CA9 Q16790 1/20 0.45
GPR27 Q9NS67 1/20 0.43
ABL1 P00519 1/20 0.42
ALDH1A1 P00352 3/20 0.41
KMT2A Q03164 2/20 0.41
MEN1 O00255 1/20 0.41
MAPK1 P28482 1/20 0.41
HIF1A Q16665 1/20 0.41
MAPT P10636 2/20 0.41
TP53 P04637 1/20 0.41
KDM4E B2RXH2 2/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29526339 1.00 FLT1 (0.50) FLT1FLT4KDRMAOBMAOA
SCHEMBL20981631 0.86 FLT1 (0.46) FLT1FLT4KDRMAOBMAOA
SCHEMBL6626508 0.85 HSD17B1 (0.44) FLT1FLT4KDRMAOBMAOA
SCHEMBL3121226 0.83 F2R (0.48) MAOBMAOASMN1; SMN2TSHRCASP1
SCHEMBL29494150 0.83 F2R (0.48) MAOBMAOASMN1; SMN2TSHRCASP1
SCHEMBL11810626 0.81 SMN1; SMN2 (0.52) FLT1FLT4KDRSMN1; SMN2TSHR
SCHEMBL1164132 0.81 FLT1 (0.51) FLT1FLT4KDRMAOBSMN1; SMN2
SCHEMBL395189 0.81 SMN1; SMN2 (0.63) FLT1FLT4KDRSMN1; SMN2TSHR
SCHEMBL15756559 0.81 MAOA (0.48) MAOBMAOAALDH1A1KMT2AMAPK1
SCHEMBL20117002 0.80 ALDH1A1 (0.50) MAOBMAOASMN1; SMN2TSHRCASP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 327 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113880786-A Synthesis method and antioxidant application of camphene aldehyde thiazole hydrazone derivative 江西农业大学 2022-01-04 CN claimed
US-12509474-B2 Inhibitors of complement factors and uses thereof ANNEXON, INC. (US) 2025-12-30 US disclosed
US-20250282748-A1 SUBSTITUTED OXOPYRIDINE DERIVATIVES BAYER PHARMA AKTIENGESELLSCHAFT (DE) 2025-09-11 US disclosed
US-12404274-B2 Macrocycles as factor xia inhibitors BRISTOL-MYERS SQUIBB COMPANY (US) 2025-09-02 US disclosed
CN-118638059-A Polymorphic form of FXIa inhibitor compound, preparation method and medical application thereof 深圳信立泰药业股份有限公司 2024-09-13 CN disclosed
CN-115515938-B Salts of FXIa inhibitor compounds, preparation method and medical application thereof 深圳信立泰药业股份有限公司 2024-05-10 CN disclosed
US-20240109920-A1 INHIBITORS OF COMPLEMENT FACTORS AND USES THEREOF ANNEXON, INC. 2024-04-04 US disclosed
CN-114685458-B Organic compound and application thereof 广州华睿光电材料有限公司 2024-03-08 CN disclosed
CN-117586179-A GPR183 antagonist and synthetic method and application thereof 中国人民解放军海军特色医学中心 2024-02-23 CN disclosed
US-20240043422-A1 METHODS FOR TREATING CANCER AND NON-NEOPLASTIC CONDITIONS PTC THERAPEUTICS, INC. (US) 2024-02-08 US disclosed
US-4259235-A REDUCTION OF PLANT GROWTH HEIGHT BASF AKTIENGESELLSCHAFT (DE) 1981-03-31 US disclosed
US-4257941-A PLANT GROWTH REGULATORS, HERBICIDES BASF AKTIENGESELLSCHAFT (DE) 1981-03-24 US disclosed
US-4251542-A Imino compounds CIBA-GEIGY CORPORATION (US) 1981-02-17 US disclosed
US-4209447-A FUNGICIDES, BACTERICIDES JANSSEN PHARMACEUTICA N.V. (BE) 1980-06-24 US disclosed
US-4189434-A PLANT GROWTH REGULATORS BASF AKTIENGESELLSCHAFT (DE) 1980-02-19 US disclosed
EP-0001271-A1 Heterocyclic norbornane derivatives, plant-growth regulating compositions containing these compounds and process for the preparation of these compositions BASF Aktiengesellschaft (DE) 1979-04-04 EP disclosed
US-4139540-A FUNGICIDE, BACTERICIDE INTERMEDIATE JANSSEN PHARMACEUTICA N.V. (BE) 1979-02-13 US disclosed
US-4130652-A 2-(Iminoethylidene)-pyrrolidines and tautomeric 2-(aminoethenyl)-1-pyrrolines CIBA-GEIGY CORPORATION (US) 1978-12-19 US disclosed
US-4044131-A B-ADRENERGIC BLOCKERS, FUNGICIDES, 4-ALKYL OR ALKYNYL, 6-ARYLOXYMETHYL AMERICAN HOME PRODUCTS CORPORATION (US) 1977-08-23 US disclosed
US-3936470-A FUNGICIDES, BACTERICIDES JANSSEN PHARMACEUTICA N.V. (BE) 1976-02-03 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240109920-A1 INHIBITORS OF COMPLEMENT FACTORS AND USES THEREOF CFB, CFH, C9 FLT1 3910/4885FLT4 4082/4885KDR 3397/4885
US-12404274-B2 Macrocycles as factor xia inhibitors TFPI, TFPI2, F11 FLT1 147/4885FLT4 310/4885KDR 603/4885
US-20240043422-A1 METHODS FOR TREATING CANCER AND NON-NEOPLASTIC CONDITIONS HDGF, POLRMT, VEGFA FLT1 21/4885FLT4 17/4885KDR 23/4885
US-12509474-B2 Inhibitors of complement factors and uses thereof SSB, UACA, CFH FLT1 3949/4885FLT4 4363/4885KDR 2637/4885
US-20250282748-A1 SUBSTITUTED OXOPYRIDINE DERIVATIVES OGFOD1, VASP, PNPO FLT1 103/4885FLT4 104/4885KDR 79/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.