Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 8/20 | 0.36 |
| ▸ | IGF1R | P08069 | 2/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.31 |
| ▸ | NAMPT | P43490 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.30 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6174451 | 0.87 | LMNA (0.40) | GAALMNAMAPK1ALDH1A1CYP3A4 | |
| SCHEMBL6175990 | 0.85 | KIF11 (0.37) | IGF1RRXFP1LMNANAMPT | |
| SCHEMBL6172433 | 0.83 | GAA (0.38) | GAARXFP1 | |
| SCHEMBL6176021 | 0.83 | IGF1R (0.34) | IGF1RRXFP1LMNAMAPK1 | |
| SCHEMBL6173243 | 0.83 | METAP2 (0.37) | IGF1RRXFP1LMNANAMPT | |
| SCHEMBL6171910 | 0.82 | NAMPT (0.47) | NAMPTCYP2C9 | |
| SCHEMBL6174116 | 0.82 | IGF1R (0.33) | IGF1RLMNA | |
| SCHEMBL6174685 | 0.82 | RXFP1 (0.36) | IGF1RRXFP1LMNANAMPT | |
| SCHEMBL6177570 | 0.81 | ALDH1A1 (0.40) | GAAIGF1RRXFP1LMNAALDH1A1 | |
| SCHEMBL6174217 | 0.81 | IGF1R (0.38) | GAAIGF1RRXFP1LMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1599464-A2 | NOVEL CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | Aventis Pharma S.A. (FR) | 2005-11-30 | — | — | EP | disclosed |
| WO-2004070050-A2 | CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | AVENTIS PHARMA S.A. (FR) | 2004-08-19 | — | — | WO | disclosed |