Sugi Predict

Sugi Predict / Compounds / SCHEMBL6186068

SCHEMBL6186068

SCHEMBL6186068

O=[N+]([O-])c1cc(Cl)cc(Cl)c1Cl

nearest known ligand 0.58

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
▸ ALDH1A1 P00352 6/20 0.58
▸ TSHR P16473 4/20 0.58
▸ MAPK1 P28482 2/20 0.57
▸ GPR35 Q9HC97 2/20 0.50
▸ VCAM1 P19320 6/20 0.48
▸ TDP1 Q9NUW8 2/20 0.48
▸ CYP3A4 P08684 2/20 0.48
▸ HPGD P15428 1/20 0.48
▸ ALOX15 P16050 1/20 0.48
▸ HIF1A Q16665 1/20 0.48
▸ TXNRD1 Q16881 1/20 0.48
▸ TXNRD3 Q86VQ6 1/20 0.48
▸ TXNRD2 Q9NNW7 1/20 0.48
▸ L3MBTL1 Q9Y468 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9452603 0.88 TSHR (0.59) ALDH1A1TSHRMAPK1GPR35VCAM1
SCHEMBL8066632 0.80 ALDH1A1 (0.75) ALDH1A1TSHRMAPK1GPR35VCAM1
SCHEMBL496363 0.80 ALDH1A1 (0.75) ALDH1A1TSHRMAPK1GPR35VCAM1
SCHEMBL31264960 0.80 ALDH1A1 (0.75) ALDH1A1TSHRMAPK1GPR35VCAM1
SCHEMBL3650611 0.79 TDP1 (0.61) ALDH1A1TSHRMAPK1GPR35VCAM1
SCHEMBL29939725 0.79 TDP1 (0.61) ALDH1A1TSHRMAPK1GPR35VCAM1
SCHEMBL25314994 0.78 TSHR (0.48) ALDH1A1TSHRMAPK1GPR35VCAM1
SCHEMBL2810707 0.78 GPR35 (0.57) ALDH1A1TSHRMAPK1GPR35VCAM1
SCHEMBL310420 0.78 GPR35 (0.69) ALDH1A1TSHRMAPK1GPR35TDP1
SCHEMBL10610184 0.78 ALDH1A1 (0.47) ALDH1A1TSHRMAPK1GPR35VCAM1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 36 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0415158-B1 Process for the preparation of chlorine substituted aromatic amines BAYER AG (DE) 1993-12-29 — — EP claimed
US-5120875-A Hydrogenating in presence of catalyst consisting of platinum, nickel and cobalt on active charcoal support BAYER AKTIENGESELLSCHAFT (DE) 1992-06-09 — — US claimed
WO-1990008142-A1 SYNTHESIS AND APPLICATION OF 1,3,6,8- AND 2,4,6,8-SUBSTITUTED DIBENZOFURANS AND DIBENZO-p-DIOXINS AS ANTITUMORIGENIC AGENTS TEXAS A&M UNIVERSITY (US) 1990-07-26 — — WO claimed
US-4230637-A Process for the preparation of chlorine-substituted aromatic amines BAYER AKTIENGESELLSCHAFT (DE) 1980-10-28 — — US claimed
EP-4667460-A1 MIR-124 INDUCER, AND PREPARATION METHOD THEREFOR AND USE THEREOF Nanjing Synnocare Pharmaceutical Technology Co., Ltd. (CN) 2025-12-24 — — EP disclosed
WO-2024169848-A1 MIR-124 INDUCER, AND PREPARATION METHOD THEREFOR AND USE THEREOF 南京同诺康医药科技有限公司 2024-08-22 — — WO disclosed
CN-103483263-B Arylpyrrol-2-yl cyanoethylamino compounds, process for their preparation and their use MERIAL LTD. (US) 2016-04-13 — — CN disclosed
EP-0994862-B1 SULPHONAMIDE DERIVATIVES BEING 5-HT6 RECEPTOR ANTAGONISTS AND PROCESS FOR THEIR PREPARATION SMITHKLINE BEECHAM PLC (GB) 2005-06-01 — — EP disclosed
EP-0820808-B1 Multi-metallic catalyst and method for producing substituted aromatic amines DEGUSSA (DE) 2002-09-04 — — EP disclosed
CN-1087294-C Novel compounds SMITHKLINE BEECHAM PLC (GB) 2002-07-10 — — CN disclosed
US-20010056035-A1 Multimetallic catalyst and process for preparing substituted aromatic amines AUER EMMANUEL (DE) 2001-12-27 — — US disclosed
US-6316450-B1 PIPERAZINE COMPOUNDS FOR TREATING DEPRESSION AND ANXIETY SMITHKLINE BEECHAM P.L.C. (GB) 2001-11-13 — — US disclosed
US-4351959-A Process for preparation of anilines substituted by chlorine in the meta-position RHONE-POULENC AGROCHIMIE (FR) 1982-09-28 — — US disclosed
US-4340759-A Process for the preparation of anilines substituted by chlorine in the meta-position RHONE-POULENC AGROCHIMIE (FR) 1982-07-20 — — US disclosed
US-4324914-A Process for preparation of anilines substituted by chlorine in the meta-position RHONE-POULENC AGROCHIMIE (FR) 1982-04-13 — — US disclosed
EP-0017205-B1 PROCESS FOR THE PREPARATION OF N-ARYL-OXAZOLIDINE-2,4-DIONES BASF Aktiengesellschaft (DE) 1982-03-31 — — EP disclosed
US-4294971-A Preparation of N-aryloxazolidine-2,4-diones BASF AKTIENGESELLSCHAFT (DE) 1981-10-13 — — US disclosed
US-4230637-A Process for the preparation of chlorine-substituted aromatic amines BAYER AKTIENGESELLSCHAFT (DE) 1980-10-28 — — US disclosed
EP-0017205-A1 Process for the preparation of N-aryl-oxazolidine-2,4-diones BASF Aktiengesellschaft (DE) 1980-10-15 — — EP disclosed
US-4059627-A HYDROGENATION OF CHLORINATED NITRO AROMATIC, NOBLE METAL CATALYST, THIOETHER BAYER AKTIENGESELLSCHAFT (DT) 1977-11-22 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20010056035-A1 Multimetallic catalyst and process for preparing substituted aromatic amines TYR, HNMT, AOC2 ALDH1A1 1959/4885TSHR 3768/4885MAPK1 1891/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.