Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 3/20 | 0.57 |
| ▸ | MAOB | P27338 | 1/20 | 0.57 |
| ▸ | MTNR1A | P48039 | 4/20 | 0.50 |
| ▸ | MTNR1B | P49286 | 4/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.36 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.35 |
| ▸ | PGR | P06401 | 1/20 | 0.35 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.35 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.35 |
| ▸ | CDC25A | P30304 | 1/20 | 0.35 |
| ▸ | CDC25B | P30305 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15944392 | 0.82 | HPGD (0.42) | MAOAMAOBALDH1A1MAPK1NPC1 | |
| SCHEMBL9621508 | 0.81 | KMT2A (0.39) | MAOAMAOBMTNR1AMTNR1BALDH1A1 | |
| SCHEMBL9621626 | 0.79 | MAOA (0.41) | MAOAMAOBMTNR1AMTNR1BSLC6A4 | |
| SCHEMBL10612729 | 0.77 | MAOA (0.44) | MAOAMAOBMTNR1AMTNR1BALDH1A1 | |
| SCHEMBL9621560 | 0.77 | HRH3 (0.40) | MAOASLC6A4 | |
| SCHEMBL10612736 | 0.77 | MAOA (0.44) | MAOAMAOBMTNR1AMTNR1BALDH1A1 | |
| SCHEMBL14490649 | 0.76 | MAOA (0.68) | MAOAMAOBMTNR1AMTNR1BALDH1A1 | |
| Fluoride SCHEMBL1336700 | 0.76 | MAOA (0.68) | MAOAMAOBMTNR1AMTNR1BALDH1A1 | |
| SCHEMBL94583 | 0.76 | MAOA (0.68) | MAOAMAOBMTNR1AMTNR1BALDH1A1 | |
| SCHEMBL10402868 | 0.76 | MAOA (0.57) | MAOAMAOBMTNR1AMTNR1BALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1425279-A4 | METHOD FOR THE PREPARATION OF CRYSTALLINE TETRAHYDROBENZOTHIEPINES | SEARLE LLC (US) | 2005-10-26 | — | — | EP | disclosed |
| US-20050090543-A1 | Method for the preparation of tetrahydrobenzothiepines | PHARMACIA CORPORATION (US) | 2005-04-28 | — | — | US | disclosed |
| US-6794544-B2 | APICAL SODIUM CO- DEPENDENT BILE ACID TRANSPORTER (ASBT) INHIBITORS | PHARMACIA CORPORATION | 2004-09-21 | — | — | US | disclosed |
| US-20040110761-A1 | Combination therapy for the prophylaxis and treatment of hyperlipidemic conditions and disorders | G.D. SEARLE LLC | 2004-06-10 | — | — | US | disclosed |
| EP-1425279-A2 | METHOD FOR THE PREPARATION OF CRYSTALLINE TETRAHYDROBENZOTHIEPINES | G.D. Searle LLC (US) | 2004-06-09 | — | — | EP | disclosed |
| US-20040082647-A1 | Method for the preparation of tetrahydrobenzothiepines | G.D. SEARLE, LLC | 2004-04-29 | — | — | US | disclosed |
| US-20030236406-A1 | Method for the preparation of tetrahydrobenzothiepines | BABIAK KEVIN A (US) | 2003-12-25 | — | — | US | disclosed |
| US-20030232834-A1 | Combination therapy for the prophylaxis and treatment of hyperlipidemic conditions and disorders | KELLER BRADLEY T (US) | 2003-12-18 | — | — | US | disclosed |
| WO-2003022804-A9 | METHOD FOR THE PREPARATION OF CRYSTALLINE TETRAHYDROBENZOTHIEPINES | SEARLE LLC (US) | 2003-12-18 | — | — | WO | disclosed |
| US-20030199515-A1 | Method for the preparation of crystalline tetrahydrobenzothiepines | G.D. SEARLE, LLC (US) | 2003-10-23 | — | — | US | disclosed |
| US-6586434-B2 | Method for the preparation of tetrahydrobenzothiepines | G.D. SEARLE, LLC | 2003-07-01 | — | — | US | disclosed |
| WO-2003022804-A2 | METHOD FOR THE PREPARATION OF CRYSTALLINE TETRAHYDROBENZOTHIEPINES | G.D. SEARLE LLC (US) | 2003-03-20 | — | — | WO | disclosed |
| EP-1286984-A2 | METHOD FOR THE PREPARATION OF TETRAHYDROBENZOTHIEPINES | Pharmacia Corporation (US) | 2003-03-05 | — | — | EP | disclosed |
| US-20020061888-A1 | Combination therapy for the prophylaxis and treatment of hyperlipidemic conditions and disorders | G.D. SEARLE LLC | 2002-05-23 | — | — | US | disclosed |
| US-20020032329-A1 | Method for the preparation of tetrahydrobenzothiepines | G.D. SEARLE LLC | 2002-03-14 | — | — | US | disclosed |
| WO-2001068637-A2 | METHOD FOR THE PREPARATION OF TETRAHYDROBENZOTHIEPINES | PHARMACIA CORPORATION (US) | 2001-09-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040110761-A1 | Combination therapy for the prophylaxis and treatment of hyperlipidemic conditions and disorders | SLC10A1, HMGCR, SLC10A2 | MAOA 1895/4885MAOB 1267/4885MTNR1A 487/4885 |
| US-20030199515-A1 | Method for the preparation of crystalline tetrahydrobenzothiepines | TPMT, MPST, SULT1A1 | MAOA 1091/4885MAOB 1081/4885MTNR1A 549/4885 |
| US-20030232834-A1 | Combination therapy for the prophylaxis and treatment of hyperlipidemic conditions and disorders | TOP2A, TOP2B, TYMP | MAOA 1154/4885MAOB 636/4885MTNR1A 2228/4885 |
| US-20020032329-A1 | Method for the preparation of tetrahydrobenzothiepines | TMT1A, THOP1, BBOX1 | MAOA 719/4885MAOB 516/4885MTNR1A 171/4885 |
| US-20020061888-A1 | Combination therapy for the prophylaxis and treatment of hyperlipidemic conditions and disorders | SLC10A1, HMGCR, SLC10A2 | MAOA 1711/4885MAOB 1312/4885MTNR1A 596/4885 |
| US-20050090543-A1 | Method for the preparation of tetrahydrobenzothiepines | TMT1A, THOP1, BBOX1 | MAOA 719/4885MAOB 516/4885MTNR1A 171/4885 |
| US-20030236406-A1 | Method for the preparation of tetrahydrobenzothiepines | TMT1A, THOP1, BBOX1 | MAOA 726/4885MAOB 516/4885MTNR1A 171/4885 |
| US-20040082647-A1 | Method for the preparation of tetrahydrobenzothiepines | TMT1A, THOP1, BBOX1 | MAOA 719/4885MAOB 516/4885MTNR1A 171/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.