Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MDM2 | Q00987 | 2/20 | 0.41 |
| ▸ | PTPN1 | P18031 | 11/20 | 0.40 |
| ▸ | EP300 | Q09472 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.38 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.37 |
| ▸ | PPARA | Q07869 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6400617 | 0.90 | NPC1 (0.44) | MDM2PTPN1EP300 | |
| SCHEMBL6204081 | 0.83 | CYP2C9 (0.42) | TSHR | |
| SCHEMBL3371893 | 0.83 | FFAR2 (0.42) | EP300TSHRFFAR2PPARGPPARA | |
| SCHEMBL6203529 | 0.74 | TSHR (0.52) | PTPN1TSHR | |
| SCHEMBL11307784 | 0.73 | MDM2 (0.51) | MDM2PPARGPPARA | |
| SCHEMBL6204077 | 0.73 | MGAM (0.50) | TSHRFFAR2 | |
| SCHEMBL6201491 | 0.72 | TSHR (0.50) | TSHR | |
| SCHEMBL6203634 | 0.72 | NTSR1 (0.57) | MDM2PTPN1NTSR1PPARGPPARA | |
| SCHEMBL1127590 | 0.71 | KMT2A (0.46) | TSHRPPARGPPARA | |
| SCHEMBL10988389 | 0.71 | MDM2 (0.53) | MDM2PPARGPPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050272036-A1 | Ketones | ASTRAZENECA AB (SE) | 2005-12-08 | — | — | US | disclosed |
| CN-1681763-A | Chemical compounds | ASTRAZENECA AB (SE) | 2005-10-12 | — | — | CN | disclosed |
| EP-1549600-A1 | KETONES | AstraZeneca AB (SE) | 2005-07-06 | — | — | EP | disclosed |
| WO-2004011410-A1 | CHEMICAL COMPOUNDS | ASTRAZENECA AB (SE) | 2004-02-05 | — | — | WO | disclosed |