Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.40 |
| ▸ | CTNNB1 | P35222 | 2/20 | 0.39 |
| ▸ | WNT3A | P56704 | 2/20 | 0.39 |
| ▸ | PARP1 | P09874 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | PTPRC | P08575 | 1/20 | 0.37 |
| ▸ | MRGPRX1 | Q96LB2 | 1/20 | 0.37 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.37 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1405144 | 0.83 | LMNA (0.58) | LMNAGAAPTGS1CTNNB1WNT3A | |
| SCHEMBL6207031 | 0.79 | CES2 (0.47) | LMNAGAANPC1RAB9ATDP1 | |
| SCHEMBL6675290 | 0.77 | LMNA (0.51) | LMNAGAANPC1RAB9APTGS1 | |
| SCHEMBL6207827 | 0.77 | HPGD (0.52) | LMNAGAANPC1RAB9ATDP1 | |
| SCHEMBL513905 | 0.76 | LMNA (0.55) | LMNAGAANPC1RAB9APTGS1 | |
| SCHEMBL6205138 | 0.76 | LMNA (0.47) | LMNAGAANPC1RAB9APTGS1 | |
| SCHEMBL10519876 | 0.76 | LMNA (0.58) | LMNAGAAPTGS1CTNNB1WNT3A | |
| SCHEMBL6205116 | 0.76 | NPC1 (0.50) | LMNANPC1RAB9AMAOB | |
| SCHEMBL6206781 | 0.76 | RAB9A (0.50) | LMNAGAANPC1RAB9ATDP1 | |
| SCHEMBL3430652 | 0.76 | LMNA (0.50) | LMNAGAACTNNB1WNT3ACNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1532128-A1 | INHIBITORS OF HCV NS5B POLYMERASE | Pharmacia & Upjohn Company LLC (US) | 2005-05-25 | — | — | EP | disclosed |
| WO-2004002977-A1 | INHIBITORS OF HCV NS5B POLYMERASE | PHARMACIA & UPJOHN COMPANY LLC (US) | 2004-01-08 | — | — | WO | disclosed |