Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 12/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | FFAR1 | O14842 | 3/20 | 0.41 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6208783 | 0.89 | ADORA3 (0.42) | GRM5CYP3A4FFAR1NPC1MAPT | |
| SCHEMBL6209016 | 0.88 | GRM5 (0.43) | GRM5FFAR1EGLN1 | |
| SCHEMBL6212636 | 0.86 | GRM5 (0.47) | GRM5KMT2ANPC1MAPTRAB9A | |
| SCHEMBL6208345 | 0.82 | ADORA3 (0.41) | GRM5NPC1MAPTRAB9ASMN1; SMN2 | |
| SCHEMBL6200156 | 0.82 | GRM5 (0.43) | GRM5CYP1A2CYP3A4FFAR1KMT2A | |
| SCHEMBL6208213 | 0.82 | GRM5 (0.43) | GRM5FFAR1KMT2ANPC1RAB9A | |
| SCHEMBL6209784 | 0.82 | GABRA2 (0.37) | GRM5KMT2ANPC1MAPTRAB9A | |
| SCHEMBL6207945 | 0.81 | TDP1 (0.34) | CYP1A2CYP3A4KMT2AMAPTSMN1; SMN2 | |
| SCHEMBL6208296 | 0.78 | GRM5 (0.45) | GRM5KMT2ANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL6502589 | 0.74 | FFAR1 (0.41) | GRM5FFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1349839-B1 | PHENYLETHENYL OR PHENYLETHINYL DERIVATIVES AS GLUTAMATE RECEPTOR ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2005-02-09 | — | — | EP | claimed |