Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 9/20 | 0.43 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.37 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.34 |
| ▸ | HRH2 | P25021 | 1/20 | 0.34 |
| ▸ | HRH1 | P35367 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6209784 | 0.88 | GABRA2 (0.37) | GRM5GABRA2GABRB2OPRM1TSHR | |
| SCHEMBL6208278 | 0.88 | LMNA (0.37) | GRM5GABRA2GABRB2KDM4ELMNA | |
| SCHEMBL6208783 | 0.88 | ADORA3 (0.42) | GRM5GABRA2GABRB2KDM4ELMNA | |
| SCHEMBL6208345 | 0.86 | ADORA3 (0.41) | GRM5GABRA2GABRB2TSHRKDM4E | |
| SCHEMBL6207660 | 0.82 | GRM5 (0.43) | GRM5KMT2AFFAR1NPC1RAB9A | |
| SCHEMBL6208296 | 0.82 | GRM5 (0.45) | GRM5KDM4ELMNAALDH1A1KMT2A | |
| SCHEMBL6199786 | 0.81 | GRM5 (0.52) | GRM5GABRA2GABRB2TSHRKDM4E | |
| SCHEMBL6209016 | 0.79 | GRM5 (0.43) | GRM5FFAR1 | |
| SCHEMBL6207945 | 0.78 | TDP1 (0.34) | TSHRKDM4ELMNAALDH1A1KMT2A | |
| SCHEMBL6212636 | 0.78 | GRM5 (0.47) | GRM5TSHRKDM4EALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1349839-B1 | PHENYLETHENYL OR PHENYLETHINYL DERIVATIVES AS GLUTAMATE RECEPTOR ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2005-02-09 | — | — | EP | claimed |