Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | JAK1 | P23458 | 1/20 | 0.34 |
| ▸ | TYK2 | P29597 | 1/20 | 0.34 |
| ▸ | JAK3 | P52333 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6209784 | 0.83 | GABRA2 (0.37) | MAPTALDH1A1NPSR1MEN1KMT2A | |
| SCHEMBL6208783 | 0.82 | ADORA3 (0.42) | MAPTALDH1A1CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL6199750 | 0.81 | MAPK1 (0.43) | TDP1PDE4BMAPTALDH1A1HSD17B10 | |
| SCHEMBL6207660 | 0.81 | GRM5 (0.43) | MAPTCYP1A2CYP3A4KMT2ASMN1; SMN2 | |
| SCHEMBL6212636 | 0.79 | GRM5 (0.47) | MAPTALDH1A1HSD17B10MEN1KMT2A | |
| SCHEMBL6208345 | 0.79 | ADORA3 (0.41) | MAPTALDH1A1HSD17B10NPSR1SMN1; SMN2 | |
| SCHEMBL6208296 | 0.79 | GRM5 (0.45) | ALDH1A1MEN1KMT2ASMN1; SMN2LMNA | |
| SCHEMBL6209016 | 0.78 | GRM5 (0.43) | TDP1 | |
| SCHEMBL6208213 | 0.78 | GRM5 (0.43) | ALDH1A1KMT2ATSHRLMNAKDM4E | |
| SCHEMBL4083809 | 0.77 | CACNA1F (0.42) | ALDH1A1NPSR1MEN1KMT2AALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1349839-B1 | PHENYLETHENYL OR PHENYLETHINYL DERIVATIVES AS GLUTAMATE RECEPTOR ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2005-02-09 | — | — | EP | claimed |