Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.53 |
| ▸ | PSIP1 | O75475 | 1/20 | 0.52 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.51 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.51 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.51 |
| ▸ | PGR | P06401 | 4/20 | 0.51 |
| ▸ | MEP1B | Q16820 | 1/20 | 0.51 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.49 |
| ▸ | ESR1 | P03372 | 1/20 | 0.49 |
| ▸ | CA1 | P00915 | 2/20 | 0.49 |
| ▸ | CA2 | P00918 | 2/20 | 0.49 |
| ▸ | CA9 | Q16790 | 2/20 | 0.49 |
| ▸ | CA12 | O43570 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4250924 | 0.89 | HSD11B1 (0.53) | HSD11B1NFE2L2FFAR4KEAP1PGR | |
| SCHEMBL11986344 | 0.87 | NFE2L2 (0.51) | HSD11B1NFE2L2FFAR4KEAP1PGR | |
| SCHEMBL13370691 | 0.85 | CA12 (0.50) | HSD11B1NFE2L2FFAR4KEAP1PGR | |
| SCHEMBL7324279 | 0.85 | HSD11B1 (0.50) | HSD11B1NFE2L2FFAR4KEAP1PGR | |
| SCHEMBL11986349 | 0.84 | HSD11B1 (0.47) | HSD11B1NFE2L2FFAR4KEAP1PGR | |
| SCHEMBL20314695 | 0.84 | MMP13 (0.47) | HSD11B1NFE2L2FFAR4KEAP1PGR | |
| SCHEMBL14773591 | 0.83 | TP53 (0.52) | PSIP1MEN1GAAMAPTKMT2A | |
| SCHEMBL14326955 | 0.82 | HSD11B1 (0.51) | HSD11B1NFE2L2FFAR4KEAP1PGR | |
| SCHEMBL4188124 | 0.82 | HSD11B1 (0.48) | HSD11B1NFE2L2FFAR4KEAP1PGR | |
| SCHEMBL3151230 | 0.82 | MTNR1B (0.56) | NFE2L2FFAR4KEAP1PGRMEP1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180179151-A1 | SULFONAMIDE DERIVATIVE AND PHARMACEUTICALLY ACCEPTABLE ACID ADDITION SALT THEREOF | UNIVERSITY OF TSUKUBA (JP) | 2018-06-28 | — | — | US | disclosed |
| US-20150105396-A1 | Chemical Compounds | PFIZER LTD (GB) | 2015-04-16 | — | — | US | disclosed |
| US-7932284-B2 | Indole sulfonamide modulators of progesterone receptors | ELI LILLY AND COMPANY (US) | 2011-04-26 | — | — | US | disclosed |
| US-20090069400-A1 | Indole Sulfonamide Modulators of Progesterone Receptors | ELI LILLY AND COMPANY | 2009-03-12 | — | — | US | disclosed |
| EP-1188747-B1 | PHENOXYPROPYLAMINE COMPOUNDS | MITSUBISHI PHARMA CORP (JP) | 2005-09-07 | — | — | EP | disclosed |
| EP-1188747-A1 | PHENOXYPROPYLAMINE COMPOUNDS | Mitsubishi Pharma Corporation (JP) | 2002-03-20 | — | — | EP | disclosed |
| US-5672615-A | MATRIX-DEGRADING METALLOPROTEINASE INHIBITORS | NOVARTIS CORPORATION (US) | 1997-09-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180179151-A1 | SULFONAMIDE DERIVATIVE AND PHARMACEUTICALLY ACCEPTABLE ACID ADDITION SALT THEREOF | HCRTR2, HCRTR1, NPSR1 | HSD11B1 538/4885PSIP1 3260/4885NFE2L2 3322/4885 |
| US-20090069400-A1 | Indole Sulfonamide Modulators of Progesterone Receptors | PGR, NPSR1, PRLHR | HSD11B1 319/4885PSIP1 1852/4885NFE2L2 2576/4885 |
| US-20150105396-A1 | Chemical Compounds | GABRA5, GABRA4, GABRA3 | HSD11B1 947/4885PSIP1 3000/4885NFE2L2 1758/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.