Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 4/20 | 0.40 |
| ▸ | SMYD3 | Q9H7B4 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.33 |
| ▸ | TAOK1 | Q7L7X3 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | PTAFR | P25105 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6213640 | 0.90 | ROCK2 (0.38) | ROCK2SMYD3LMNAGPR119TAOK1 | |
| SCHEMBL6210763 | 0.89 | ROCK2 (0.36) | ROCK2GPR119TAOK1 | |
| SCHEMBL6212956 | 0.88 | ROCK2 (0.41) | ROCK2LMNAGPR119TAOK1PTAFR | |
| SCHEMBL6215209 | 0.88 | ROCK2 (0.40) | ROCK2SMYD3LMNAALDH1A1PTAFR | |
| SCHEMBL6208718 | 0.88 | LMNA (0.42) | SMYD3LMNAALDH1A1 | |
| SCHEMBL6209450 | 0.88 | CXCR3 (0.43) | SMYD3LMNAPTAFR | |
| SCHEMBL6211570 | 0.88 | SLC6A5 (0.38) | SMYD3LMNA | |
| SCHEMBL6211038 | 0.88 | CTSK (0.41) | SMYD3LMNAALDH1A1 | |
| SCHEMBL6210489 | 0.87 | CHRM4 (0.39) | SMYD3LMNA | |
| SCHEMBL6211651 | 0.87 | NAMPT (0.38) | SMYD3LMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1546150-A1 | BIOLOGICALLY ACTIVE COMPOUNDS | Amura Therapeutics Limited (GB) | 2005-06-29 | — | — | EP | claimed |
| WO-2004007501-A1 | BIOLOGICALLY ACTIVE COMPOUNDS | AMURA THERAPEUTICS LIMITED (GB) | 2004-01-22 | — | — | WO | claimed |
| EP-1546150-A1 | BIOLOGICALLY ACTIVE COMPOUNDS | Amura Therapeutics Limited (GB) | 2005-06-29 | — | — | EP | disclosed |
| WO-2004007501-A1 | BIOLOGICALLY ACTIVE COMPOUNDS | AMURA THERAPEUTICS LIMITED (GB) | 2004-01-22 | — | — | WO | disclosed |