Butadiene

Butadiene

SCHEMBL625826

C=CC=C.CCOC(C)OCC

nearest known ligand 0.71

Full drug profile on Sugi Atlas →

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
LMNA P02545 1/20 0.71
THRB P10828 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Propene SCHEMBL560443 0.88 LMNA (0.71) LMNATHRB
Acrolein SCHEMBL157907 0.87 LMNA (0.60) LMNATHRB
SCHEMBL5960679 0.86 LMNA (0.67) LMNATHRB
Vinyl Chloride SCHEMBL4142982 0.86 LMNA (0.67) LMNATHRB
Acrolein SCHEMBL3930769 0.85 LMNA (0.57) LMNATHRB
Ethylene SCHEMBL555416 0.84 LMNA (0.86) LMNATHRB
Ethylene SCHEMBL3362390 0.84 LMNA (0.86) LMNATHRB
SCHEMBL9459 0.84
SCHEMBL2094168 0.84 LMNA (1.00) LMNATHRB
Vinyl Ether SCHEMBL8399501 0.83 LMNA (0.63) LMNATHRB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 85 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20130190409-A1 DRUG DELIVERY VEHICLES, METHODS OF MANUFACTURE, AND METHODS OF USE THEREOF UNIVERSITY OF MASSACHUSETTS (US) 2013-07-25 US claimed
US-8420121-B2 Drug delivery vehicles, methods of manufacture, and methods of use thereof UNIVERSITY OF MASSACHUSETTS (US) 2013-04-16 US claimed
US-20110200675-A1 DRUG DELIVERY VEHICLES, METHODS OF MANUFACTURE, AND METHODS OF USE THEREOF UNIVERSITY OF MASSACHUSETTS (US) 2011-08-18 US claimed
US-20210252156-A1 METHODS OF TREATING NAUSEA UTILIZING SEMI-SOLID DELIVERY VEHICLE COMPOSITIONS COMPRISING GRANISETRON HERON THERAPEUTICS INC (US) 2021-08-19 US disclosed
EP-3834817-A1 SEMI-SOLID DELIVERY VEHICLE AND PHARMACEUTICAL COMPOSITIONS Heron Therapeutics, Inc. (US) 2021-06-16 EP disclosed
US-20200405866-A1 METHODS OF TREATING NAUSEA UTILIZING SEMI-SOLID DELIVERY VEHICLE COMPOSITIONS COMPRISING GRANISETRON HERON THERAPEUTICS, INC. 2020-12-31 US disclosed
EP-3424492-B1 SEMI-SOLID DELIVERY VECHICLE AND PHARMACEUTICAL COMPOSITIONS HERON THERAPEUTICS INC (US) 2020-05-27 EP disclosed
US-10357570-B2 Methods of treating nausea utilizing semi-solid delivery vehicle compositions comprising granisetron HERON THERAPEUTICS, INC. (US) 2019-07-23 US disclosed
EP-3424492-A1 SEMI-SOLID DELIVERY VECHICLE AND PHARMACEUTICAL COMPOSITIONS Heron Therapeutics, Inc. (US) 2019-01-09 EP disclosed
US-20180339052-A1 METHODS OF TREATING NAUSEA UTILIZING SEMI-SOLID DELIVERY VEHICLE COMPOSITIONS COMPRISING GRANISETRON HERCULES CAPITAL, INC., AS AGENT 2018-11-29 US disclosed
EP-2902012-B1 Semi-solid delivery vehicle and pharmaceutical compositions HERON THERAPEUTICS INC (US) 2018-08-08 EP disclosed
US-20020037300-A1 Semi-solid delivery vehicle and pharmaceutical compositions HERON THERAPEUTICS, INC. (F/K/A A.P. PHARMA, INC.) 2002-03-28 US disclosed
WO-2001085139-A2 SEMI-SOLID DELIVERY VEHICLE AND PHARMACEUTICAL COMPOSITIONS ADVANCED POLYMER SYSTEMS, INC. (US) 2001-11-15 WO disclosed
WO-1991011466-A1 CROSS-LINKABLE VINYL ETHER POLYACETAL OLIGOMERS ISP INVESTMENTS INC. (US) 1991-08-08 WO disclosed
US-5036112-A Cationic radiation curable containing photoimitator; coatings GAF CHEMICALS CORPORATION (US) 1991-07-30 US disclosed
EP-0051667-B1 POLYMERS OF POLYKETENE ACETALS AND POLYOLS SRI INTERNATIONAL (US) 1986-03-05 EP disclosed
US-4230813-A CROSSLINKED STYRENE TERPOLYMER ADDITIVE HOOKER CHEMICALS & PLASTICS CORP. (US) 1980-10-28 US disclosed
US-4125702-A Additive for low profile polymerizable unsaturated polyester molding composition HOOKER CHEMICALS & PLASTICS CORP. (US) 1978-11-14 US disclosed
US-4052370-A POLYURETHANES THE FIRESTONE TIRE & RUBBER COMPANY (US) 1977-10-04 US disclosed
US-4043988-A Low profile polyester molding composition HOOKER CHEMICALS & PLASTICS CORPORATION (US) 1977-08-23 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020037300-A1 Semi-solid delivery vehicle and pharmaceutical compositions LIPA, CEL, SORD LMNA 3823/4885THRB 4373/4885
US-20110200675-A1 DRUG DELIVERY VEHICLES, METHODS OF MANUFACTURE, AND METHODS OF USE THEREOF OGFR, OPRL1, OPRK1 LMNA 4426/4885THRB 2073/4885
US-20200405866-A1 METHODS OF TREATING NAUSEA UTILIZING SEMI-SOLID DELIVERY VEHICLE COMPOSITIONS COMPRISING GRANISETRON LPXN, CRH, NTSR1 LMNA 3974/4885THRB 3672/4885
US-20210252156-A1 METHODS OF TREATING NAUSEA UTILIZING SEMI-SOLID DELIVERY VEHICLE COMPOSITIONS COMPRISING GRANISETRON LPXN, CRH, NTSR1 LMNA 3974/4885THRB 3672/4885
US-10357570-B2 Methods of treating nausea utilizing semi-solid delivery vehicle compositions comprising granisetron LPXN, CRH, NTSR1 LMNA 3974/4885THRB 3672/4885
US-20180339052-A1 METHODS OF TREATING NAUSEA UTILIZING SEMI-SOLID DELIVERY VEHICLE COMPOSITIONS COMPRISING GRANISETRON LPXN, CRH, NTSR1 LMNA 3974/4885THRB 3672/4885
US-20130190409-A1 DRUG DELIVERY VEHICLES, METHODS OF MANUFACTURE, AND METHODS OF USE THEREOF OGFR, OPRL1, OPRK1 LMNA 4426/4885THRB 2073/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.