Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 6/20 | 0.46 |
| ▸ | SYK | P43405 | 1/20 | 0.39 |
| ▸ | CDK2 | P24941 | 9/20 | 0.38 |
| ▸ | CCNE1 | P24864 | 8/20 | 0.38 |
| ▸ | CCND1 | P24385 | 5/20 | 0.38 |
| ▸ | CDK6 | Q00534 | 5/20 | 0.38 |
| ▸ | CDK1 | P06493 | 5/20 | 0.38 |
| ▸ | CCNB1 | P14635 | 5/20 | 0.38 |
| ▸ | CDK4 | P11802 | 4/20 | 0.38 |
| ▸ | CCND3 | P30281 | 4/20 | 0.38 |
| ▸ | IDH1 | O75874 | 1/20 | 0.37 |
| ▸ | IDH2 | P48735 | 1/20 | 0.37 |
| ▸ | SFRP1 | Q8N474 | 1/20 | 0.36 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.36 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL626704 | 0.89 | CCNE1 (0.43) | CDK2CCNE1CCND1CDK6CDK1 | |
| SCHEMBL624394 | 0.87 | CCNE1 (0.41) | CDK2CCNE1CCND1CDK6CDK1 | |
| SCHEMBL625860 | 0.86 | GPR119 (0.47) | GPR119SYK | |
| SCHEMBL625128 | 0.85 | CCNA2 (0.46) | GPR119SYKCDK2IDH1IDH2 | |
| SCHEMBL625456 | 0.83 | MAP3K12 (0.41) | GPR119SYKCDK2CCNE1CCND1 | |
| SCHEMBL626207 | 0.83 | MAP3K12 (0.46) | CDK2CCNE1CCND1CDK6CDK1 | |
| SCHEMBL625408 | 0.77 | MAP4K1 (0.39) | SYKCDK2CCNA2 | |
| SCHEMBL626165 | 0.77 | IDO1 (0.47) | CDK2CCNE1CCND1CDK6CDK1 | |
| SCHEMBL2121138 | 0.76 | PIK3CA (0.56) | ALK | |
| SCHEMBL626703 | 0.75 | PIK3CA (0.53) | CDK2CCNE1CCND1CDK6CDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012020215-A1 | AMINO- IMIDAZOLOTHIADIAZOLES FOR USE AS PROTEIN OR LIPID KINASE INHIBITORS | CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS (CNIO) (ES) | 2012-02-16 | — | — | WO | disclosed |