Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K12 | Q12852 | 5/20 | 0.41 |
| ▸ | CDK2 | P24941 | 2/20 | 0.39 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.39 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.38 |
| ▸ | SYK | P43405 | 1/20 | 0.38 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.37 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.36 |
| ▸ | CDK1 | P06493 | 1/20 | 0.36 |
| ▸ | CDK4 | P11802 | 1/20 | 0.36 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.36 |
| ▸ | CCND1 | P24385 | 1/20 | 0.36 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.36 |
| ▸ | CCND3 | P30281 | 1/20 | 0.36 |
| ▸ | CDK7 | P50613 | 1/20 | 0.36 |
| ▸ | CDK9 | P50750 | 1/20 | 0.36 |
| ▸ | CCNH | P51946 | 1/20 | 0.36 |
| ▸ | MNAT1 | P51948 | 1/20 | 0.36 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.36 |
| ▸ | AKT1 | P31749 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL625128 | 0.91 | CCNA2 (0.46) | MAP3K12CDK2CCNA2GPR119SYK | |
| SCHEMBL625455 | 0.87 | PIK3CA (0.43) | MAP3K12GPR119RIPK1PIK3CA | |
| SCHEMBL626207 | 0.84 | MAP3K12 (0.46) | MAP3K12CDK2PIK3CACDK1CDK4 | |
| SCHEMBL625861 | 0.83 | GPR119 (0.46) | CDK2CCNA2GPR119SYKCDK1 | |
| SCHEMBL625408 | 0.83 | MAP4K1 (0.39) | MAP3K12CDK2CCNA2SYKPIK3CA | |
| SCHEMBL626892 | 0.82 | PIK3CA (0.42) | MAP3K12PIK3CAMAP4K1 | |
| SCHEMBL624428 | 0.82 | MAP3K12 (0.47) | MAP3K12SYKPIK3CA | |
| SCHEMBL625754 | 0.81 | MAP3K12 (0.40) | MAP3K12PIK3CA | |
| SCHEMBL624985 | 0.80 | KDM4E (0.40) | MAP3K12GPR119SYKPIK3CAMAP4K1 | |
| SCHEMBL627309 | 0.79 | MAP3K12 (0.46) | MAP3K12PIK3CAMAP4K1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012020215-A1 | AMINO- IMIDAZOLOTHIADIAZOLES FOR USE AS PROTEIN OR LIPID KINASE INHIBITORS | CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS (CNIO) (ES) | 2012-02-16 | — | — | WO | disclosed |