SCHEMBL6282101

SCHEMBL6282101

Fc1[c]cc(F)c(-c2ccc(F)c(F)c2)c1

nearest known ligand 0.36

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
AKR1C3 P42330 1/20 0.36
AKR1C2 P52895 1/20 0.36
NOTUM Q6P988 1/20 0.35
CYP17A1 P05093 1/20 0.33
CYP11B1 P15538 1/20 0.33
CYP11B2 P19099 1/20 0.33
HDAC1 Q13547 1/20 0.32
HDAC2 Q92769 1/20 0.32
PDE3B Q13370 1/20 0.32
PDE3A Q14432 1/20 0.32
MAOB P27338 1/20 0.32
HSD17B1 P14061 1/20 0.32
HSD17B2 P37059 1/20 0.32
TGFBR1 P36897 1/20 0.31
KMO O15229 1/20 0.30
PTGS2 P35354 1/20 0.30
DYRK1A Q13627 1/20 0.30
USP7 Q93009 1/20 0.30
SLC22A12 Q96S37 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28237986 0.83 KIF11 (0.37)
SCHEMBL2590095 0.82 PTGS2 (0.38) MAOBPTGS2
SCHEMBL6287168 0.73 CA9 (0.37) PDE3BPDE3A
SCHEMBL27552355 0.72 CTSL (0.33) PDE3BPDE3A
SCHEMBL1275685 0.72 AHR (0.38) CYP11B1CYP11B2KMOPTGS2
SCHEMBL149390 0.70
SCHEMBL13741967 0.69 CYP17A1 (0.52) NOTUMCYP17A1CYP11B1CYP11B2HSD17B1
SCHEMBL17515034 0.69 KMO (0.36) KMO
SCHEMBL17514641 0.68 PTGS2 (0.42) AKR1C3AKR1C2PTGS2
SCHEMBL1275341 0.68 CHRNB4 (0.36)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-1284626-C Fluorinated zwitterionic cocatalyst activators for olefin polymerization EXXONMOBIL CHEM PATENTS INC (US) 2006-11-15 CN disclosed
US-6919291-B2 Fluorinated zwitterionic cocatalyst activators for olefin polymerization EXXONMOBIL CHEMICAL PATENTS INC. (US) 2005-07-19 US disclosed
US-20040110631-A1 Fluorinated zwitterionic cocatalyst activators for olefin polymerization EXXONMOBIL CHEMICAL PATENTS INC. 2004-06-10 US disclosed
CN-1477995-A Fluorinated zwitterionic cocatalyst activators for olefin polymerization 埃克森美孚化学专利公司 2004-02-25 CN disclosed
EP-1349653-A2 FLUORINATED ZWITTERIONIC COCATALYST ACTIVATORS FOR OLEFIN POLYMERIZATION ExxonMobil Chemical Patents Inc. (US) 2003-10-08 EP disclosed
WO-2002036639-A2 FLUORINATED ZWITTERIONIC COCATALYST ACTIVATORS FOR OLEFIN POLYMERIZATION EXXONMOBIL CHEMICAL PATENTS INC. (US) 2002-05-10 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040110631-A1 Fluorinated zwitterionic cocatalyst activators for olefin polymerization FZD7, FOS, COG4 AKR1C3 2633/4885AKR1C2 3233/4885NOTUM 213/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.