Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 1/20 | 0.36 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.33 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.33 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.30 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.30 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6294012 | 0.91 | KEAP1 (0.39) | KEAP1NFE2L2GABRG2GABRB3GABRA3 | |
| SCHEMBL6297203 | 0.85 | GABRG2 (0.39) | KEAP1NFE2L2GABRG2GABRB3GABRA3 | |
| SCHEMBL2657024 | 0.73 | KEAP1 (0.40) | KEAP1NFE2L2GABRG2GABRB3GABRA3 | |
| SCHEMBL2657167 | 0.71 | KEAP1 (0.38) | KEAP1NFE2L2PTGS2GABRG2GABRB3 | |
| SCHEMBL5228078 | 0.69 | GABRG2 (0.44) | GABRG2GABRB3GABRA3 | |
| SCHEMBL6292914 | 0.66 | DCTPP1 (0.38) | KEAP1NFE2L2GABRG2GABRB3GABRA3 | |
| SCHEMBL6292592 | 0.66 | GABRG2 (0.40) | KEAP1NFE2L2PTGS2GABRG2GABRB3 | |
| SCHEMBL2658685 | 0.63 | GABRG2 (0.41) | KEAP1NFE2L2GABRG2GABRB3GABRA3 | |
| SCHEMBL7669971 | 0.61 | GABRA1 (0.55) | KEAP1NFE2L2PTGS2GABRG2GABRB3 | |
| SCHEMBL2658588 | 0.61 | KMT2A (0.38) | KEAP1NFE2L2GABRG2GABRB3GABRA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6872720-B2 | Pyrazolo-triazine derivatives as ligands for gaba receptors | MERCK SHARP & DOHME LTD. | 2005-03-29 | — | — | US | disclosed |
| US-20030060467-A1 | Pyrazolo-triazine derivatives as ligands for gaba receptors | MERCK SHARP & DOHME LTD. (GB) | 2003-03-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030060467-A1 | Pyrazolo-triazine derivatives as ligands for gaba receptors | GABRA5, GABRA3, GABRA4 | KEAP1 1809/4885NFE2L2 3035/4885PTGS2 2944/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.