Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NFE2L2 | Q16236 | 3/20 | 0.53 |
| ▸ | RELA | Q04206 | 3/20 | 0.53 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | CASP3 | P42574 | 2/20 | 0.42 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.42 |
| ▸ | SENP6 | Q9GZR1 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2250015 | 0.81 | TRPA1 (0.47) | NFE2L2RELATRPA1ALDH1A1MAPT | |
| SCHEMBL8397406 | 0.80 | TAAR1 (0.45) | NFE2L2ALDH1A1CYP2A6MEN1KMT2A | |
| SCHEMBL10806504 | 0.78 | L3MBTL1 (0.54) | TRPA1ALDH1A1MAPTNPC1RAB9A | |
| SCHEMBL5580077 | 0.75 | LTA4H (0.57) | TRPA1ALDH1A1SMN1; SMN2MAPTNPC1 | |
| SCHEMBL11302811 | 0.74 | SMN1; SMN2 (0.51) | NFE2L2ALDH1A1SMN1; SMN2MAPTNPC1 | |
| SCHEMBL21340831 | 0.74 | MAOB (0.65) | RELAALDH1A1SMN1; SMN2MAPTNPC1 | |
| SCHEMBL8965499 | 0.73 | MEN1 (0.43) | NFE2L2RELAALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL5360664 | 0.72 | NFE2L2 (0.61) | NFE2L2RELAALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL1930129 | 0.72 | ALDH1A1 (0.61) | NFE2L2RELATRPA1ALDH1A1SMN1; SMN2 | |
| SCHEMBL2123173 | 0.72 | LTA4H (0.57) | NFE2L2TRPA1ALDH1A1SMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1534680-B1 | PRENYLATION INHIBITORS AND METHODS OF THEIR SYNTHESIS AND USE | PHARMACO INVESTMENTS INC (US) | 2012-02-22 | — | — | EP | disclosed |