Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.70 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.70 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.70 |
| ▸ | CES1 | P23141 | 2/20 | 0.63 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.56 |
| ▸ | HPGD | P15428 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.47 |
| ▸ | MAOA | P21397 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | MAOB | P27338 | 2/20 | 0.46 |
| ▸ | MIF | P14174 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | BCHE | P06276 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL696955 | 1.00 | ALDH1A1 (0.70) | ALDH1A1CYP1A2CYP2C19CES1L3MBTL1 | |
| SCHEMBL7270862 | 1.00 | ALDH1A1 (0.70) | ALDH1A1CYP1A2CYP2C19CES1L3MBTL1 | |
| SCHEMBL2589100 | 0.89 | L3MBTL1 (0.68) | ALDH1A1CYP1A2CYP2C19CES1L3MBTL1 | |
| SCHEMBL2589102 | 0.89 | L3MBTL1 (0.68) | ALDH1A1CYP1A2CYP2C19CES1L3MBTL1 | |
| SCHEMBL2733083 | 0.84 | HPGD (0.77) | ALDH1A1CYP1A2CYP2C19CES1L3MBTL1 | |
| SCHEMBL29453066 | 0.84 | HPGD (0.77) | ALDH1A1CYP1A2CYP2C19CES1L3MBTL1 | |
| SCHEMBL1201521 | 0.84 | HPGD (0.77) | ALDH1A1CYP1A2CYP2C19CES1L3MBTL1 | |
| SCHEMBL1201517 | 0.84 | HPGD (0.77) | ALDH1A1CYP1A2CYP2C19CES1L3MBTL1 | |
| SCHEMBL29417938 | 0.84 | HPGD (0.77) | ALDH1A1CYP1A2CYP2C19CES1L3MBTL1 | |
| SCHEMBL2281246 | 0.82 | ALDH1A1 (1.00) | ALDH1A1CYP1A2CYP2C19CES1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10000500-B2 | Coelenterazine analogues | PROMEGA CORPORATION (US) | 2018-06-19 | — | — | US | disclosed |
| US-20180030059-A1 | COELENTERAZINE ANALOGUES | JPMORGAN CHASE BANK, N.A., AS COLLATERAL AGENT | 2018-02-01 | — | — | US | disclosed |
| US-8846277-B2 | Compound, polymerizable composition, color filter, and method of producing the same, solid-state imaging device, and planographic printing plate precursor | FUJIFILM CORPORATION (JP) | 2014-09-30 | — | — | US | disclosed |
| WO-2014145512-A2 | POTENT SMALL MOLECULE INHIBITORS OF AUTOPHAGY, AND METHODS OF USE THEREOF | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2014-09-18 | — | — | WO | disclosed |
| US-8703366-B2 | — | — | 2014-04-22 | — | — | US | disclosed |
| US-8569294-B2 | 2-(cyclic amino)-pyrimidone derivatives | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2013-10-29 | — | — | US | disclosed |
| US-20110267714-A1 | NOVEL COMPOUND, POLYMERIZABLE COMPOSITION, COLOR FILTER, AND METHOD OF PRODUCING THE SAME, SOLID-STATE IMAGING DEVICE, AND PLANOGRAPHIC PRINTING PLATE PRECURSOR | FUJIFILM CORPORATION (JP) | 2011-11-03 | — | — | US | disclosed |
| US-20090233918-A1 | 2-(CYCLIC AMINO)-PYRIMIDONE DERIVATIVES | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2009-09-17 | — | — | US | disclosed |
| US-6838455-B2 | Deoxyamino acid compounds, pharmaceutical compositions comprising same, and methods for inhibiting beta-amyloid peptide release and/or its synthesis by use of such compounds | ATHENA NEUROSCIENCES, INC. (US) | 2005-01-04 | — | — | US | disclosed |
| US-20030149022-A1 | Deoxyamino acid compounds, pharmaceutical compositions comprising same, and methods for inhibiting beta-amyloid peptide release and/or its synthesis by use of such compounds | AUDIA JAMES E (US) | 2003-08-07 | — | — | US | disclosed |
| US-6552013-B1 | For therapy of Alzheimer's disease | ELAN PHARMACEUTICALS, INC. | 2003-04-22 | — | — | US | disclosed |
| EP-1089977-A1 | COMPOUNDS FOR INHIBITING BETA-AMYLOID PEPTIDE RELEASE AND/OR ITS SYNTHESIS | Elan Pharmaceuticals, Inc. (US) | 2001-04-11 | — | — | EP | disclosed |
| WO-1999067219-A1 | COMPOUNDS FOR INHIBITING BETA-AMYLOID PEPTIDE RELEASE AND/OR ITS SYNTHESIS | ELAN PHARMACEUTICALS, INC. (US) | 1999-12-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10000500-B2 | Coelenterazine analogues | GLB1, TCF7L2, SI | ALDH1A1 3416/4885CYP1A2 2617/4885CYP2C19 3378/4885 |
| US-20110267714-A1 | NOVEL COMPOUND, POLYMERIZABLE COMPOSITION, COLOR FILTER, AND METHOD OF PRODUCING THE SAME, SOLID-STATE IMAGING DEVICE, AND PLANOGRAPHIC PRINTING PLATE PRECURSOR | SPOP, SMCHD1, PPOX | ALDH1A1 1491/4885CYP1A2 713/4885CYP2C19 290/4885 |
| US-20090233918-A1 | 2-(CYCLIC AMINO)-PYRIMIDONE DERIVATIVES | MAPT, PRMT1, PSEN1 | ALDH1A1 3952/4885CYP1A2 2460/4885CYP2C19 2411/4885 |
| US-20030149022-A1 | Deoxyamino acid compounds, pharmaceutical compositions comprising same, and methods for inhibiting beta-amyloid peptide release and/or its synthesis by use of such compounds | APP, IAPP, BACE1 | ALDH1A1 2282/4885CYP1A2 3996/4885CYP2C19 3267/4885 |
| US-20180030059-A1 | COELENTERAZINE ANALOGUES | GLB1, SI, TCF7L2 | ALDH1A1 3541/4885CYP1A2 2586/4885CYP2C19 3234/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.