SCHEMBL6318834

SCHEMBL6318834

COc1cccc(C(c2ccccc2)(c2ccccc2OC)[C@]2(n3ccc(=O)[nH]c3=O)C[C@H](O)[C@@H](CO)O2)c1

nearest known ligand 0.33

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
DUT P33316 10/20 0.33
LMNA P02545 1/20 0.30
MAPK1 P28482 1/20 0.30
HTT P42858 1/20 0.30
TDP1 Q9NUW8 1/20 0.30
L3MBTL1 Q9Y468 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14764632 0.89
SCHEMBL7209223 0.85 SLC28A1 (0.32) DUT
SCHEMBL7206853 0.82 DUT (0.32) DUT
SCHEMBL7863893 0.81 RNASE1 (0.37)
SCHEMBL9755145 0.81 RNASE1 (0.38)
SCHEMBL7212072 0.80 DUT (0.31) DUT
SCHEMBL1706305 0.79 RNASE1 (0.38)
SCHEMBL5671911 0.79 SLC28A1 (0.35) DUT
SCHEMBL3612838 0.79 TK1 (0.38) LMNA
SCHEMBL20636773 0.79 LMNA (0.38) LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6864049-B1 Method for producing hybridization complexes whose stability is substantially independent of the base composition of two hybridized nucleic acid molecules APPLIGENE-ONCOR S.A. (FR) 2005-03-08 US disclosed
US-6090932-A Method of preparation of known and novel 2'-modified nucleosides by intramolecular nucleophilic displacement PROLIGO LLC (US) 2000-07-18 US disclosed
US-5192749-A Viricide, AIDS SYNTEX (U.S.A.) INC. (US) 1993-03-09 US disclosed