Known targets — ChEMBL curated mechanism
ABCC9ABL1ACEACHEACVR1ADORA1ADORA2AADORA2BADORA3ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALOX5ATP4AATP4BBCRBTKCACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGCRBNCUL4ACXCR1CXCR2DDB1DDCDHFRDPP4DRD2DRD3DRD4EGFRERBB2ERBB4ESR1ESR2FDPSFKBP1AFLT1FLT3FLT4GARTGHSRGRIA1GRIA2GRIA3GRIA4GRIK1GRIK2GRIK3GRIK4GRIK5GRIN2AGSK3AGSK3BHDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IDH1IDH2IMPA1ITGA2BITGB3JAK1JAK2JAK3KCNJ11KCNK3KCNK9KDRKITMEN1METMMP1MMP13MMP7MMP8NANOD2NS5bODC1OPG057OPRD1OPRK1OPRM1PPARP1PARP2PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PKLRPPARDPPATPTGS1PTGS2RBX1ROCK1ROCK2RRM1RRM2RRM2BSCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC10A2SLC5A2SLC6A2SLC6A3SLC6A4SLC9A3SYKTACR1THRATHRBTOP1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYK2TYMSVDRampCblablaT-3blaT-4blaT-5blaT-6blaUOE-1dacAdacBdacCfolAfolPftsIgyrAgyrBileSmecAmrcAmrcBmrdAparCparEpbp2pbp4pbpApbpFrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUthyAykgMykgO
The experimentally established mechanism targets of Toluene. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 2/20 | 0.46 |
| ▸ | MEN1 known ✓ | O00255 | 2/20 | 0.40 |
| ▸ | NOD2 known ✓ | Q9HC29 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 4/20 | 0.46 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | CA12 | O43570 | 5/20 | 0.44 |
| ▸ | CA9 | Q16790 | 5/20 | 0.44 |
| ▸ | CA2 | P00918 | 3/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 5/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | GFER | P55789 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Toluene SCHEMBL3973761 | 0.82 | ALOX12 (0.61) | LMNAALOX12ACHETSHRCA12 | |
| Toluene SCHEMBL457751 | 0.81 | ALOX12 (0.48) | LMNAALOX12ACHETSHRCA12 | |
| Toluene SCHEMBL7188331 | 0.81 | LMNA (0.48) | LMNAALOX12ACHETSHRCA12 | |
| Toluene SCHEMBL2780838 | 0.80 | ALOX12 (0.58) | LMNAALOX12ACHETSHRCA12 | |
| Toluene SCHEMBL7340462 | 0.80 | ALOX12 (0.58) | LMNAALOX12ACHETSHRCA12 | |
| Toluene SCHEMBL8100461 | 0.80 | ALOX12 (0.58) | LMNAALOX12ACHETSHRCA12 | |
| Toluene SCHEMBL10575248 | 0.78 | ALOX12 (0.50) | LMNAALOX12ACHETSHRCA12 | |
| Toluene SCHEMBL8368950 | 0.78 | ALOX12 (0.55) | LMNAALOX12ACHETSHRCA12 | |
| Toluene SCHEMBL7340467 | 0.78 | TSHR (0.55) | LMNAALOX12ACHETSHRCA12 | |
| Toluene SCHEMBL7528835 | 0.77 | ALOX12 (0.61) | LMNAALOX12ACHETSHRCA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 77 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2865743-B1 | Improvements in dispensing devices | RECKITT BENCKISER LLC (US) | 2024-03-27 | — | — | EP | disclosed |
| EP-2952570-B1 | IMPROVEMENTS IN DISPENSING DEVICES AND COMPOSITIONS THEREFOR | RECKITT BENCKISER LLC (US) | 2021-07-28 | — | — | EP | disclosed |
| EP-2191077-B1 | CAGELESS DISPENSING DEVICE | RECKITT BENCKISER LLC (US) | 2017-03-15 | — | — | EP | disclosed |
| EP-3088616-A1 | METHOD FOR PRODUCTION OF DISPENSING DEVICES | Reckitt Benckiser LLC (US) | 2016-11-02 | — | — | EP | disclosed |
| EP-2310583-B1 | DISPENSING DEVICE FOR TOILET BOWL | RECKITT BENCKISER LLC (US) | 2016-10-05 | — | — | EP | disclosed |
| US-9334640-B2 | Cageless dispensing device | RECKITT BENCKISER LLC. (US) | 2016-05-10 | — | — | US | disclosed |
| EP-2952570-A1 | IMPROVEMENTS IN DISPENSING DEVICES AND COMPOSITIONS THEREFOR | Reckitt Benckiser LLC (US) | 2015-12-09 | — | — | EP | disclosed |
| EP-1996691-B1 | IMPROVEMENTS IN DISPENSING DEVICES | RECKITT BENCKISER LLC (US) | 2015-05-06 | — | — | EP | disclosed |
| EP-2865743-A1 | Improvements in dispensing devices | Reckitt Benckiser LLC (US) | 2015-04-29 | — | — | EP | disclosed |
| US-8966674-B2 | Dispensing device for toilet bowl | RECKITT BENCKISER LLC (US) | 2015-03-03 | — | — | US | disclosed |
| EP-1781767-A1 | IMPROVEMENTS IN LAVATORY BLOCK COMPOSITIONS | Reckitt Benckiser Inc. (US) | 2007-05-09 | — | — | EP | disclosed |
| US-20070092477-A1 | Cleaning compositions | RECKITT BENCKISER INC. (US) | 2007-04-26 | — | — | US | disclosed |
| US-20070003500-A1 | Cleaning compositions | RECKITT BENCKISER INC. (US) | 2007-01-04 | — | — | US | disclosed |
| WO-2006136773-A1 | LAVATORY BLOCK COMPOSITION | RECKITT BENCKISER INC. (US) | 2006-12-28 | — | — | WO | disclosed |
| EP-1685230-A1 | CLEANING COMPOSITIONS | Reckitt Benckiser Inc. (US) | 2006-08-02 | — | — | EP | disclosed |
| EP-1685231-A1 | CLEANING COMPOSITIONS | Reckitt Benckiser Inc. (US) | 2006-08-02 | — | — | EP | disclosed |
| WO-2006013318-A1 | IMPROVEMENTS IN LAVATORY BLOCK COMPOSITIONS | RECKITT BENCKISER INC (US) | 2006-02-09 | — | — | WO | disclosed |
| WO-2005052111-A1 | CLEANING COMPOSITIONS | RECKITT BENCKISER INC (US) | 2005-06-09 | — | — | WO | disclosed |
| WO-2005052110-A1 | CLEANING COMPOSITIONS | RECKITT BENCKISER INC (US) | 2005-06-09 | — | — | WO | disclosed |
| US-4289640-A | IMPROVED FOAMING AND DEGREASING PROPERTIES | COLGATE-PALMOLIVE COMPANY (US) | 1981-09-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070092477-A1 | Cleaning compositions | WASF2, NOTUM, DBF4 | ACHE 58/4885MEN1 4705/4885NOD2 3884/4885 |
| US-20070003500-A1 | Cleaning compositions | WASF2, NOTUM, ASF1A | ACHE 128/4885MEN1 4815/4885NOD2 3580/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.