Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.51 |
| ▸ | MMP2 | P08253 | 10/20 | 0.49 |
| ▸ | MMP9 | P14780 | 10/20 | 0.49 |
| ▸ | MMP8 | P22894 | 6/20 | 0.49 |
| ▸ | MMP14 | P50281 | 6/20 | 0.49 |
| ▸ | MMP3 | P08254 | 5/20 | 0.49 |
| ▸ | MMP13 | P45452 | 5/20 | 0.49 |
| ▸ | MMP1 | P03956 | 5/20 | 0.49 |
| ▸ | ADAM17 | P78536 | 2/20 | 0.49 |
| ▸ | MCL1 | Q07820 | 3/20 | 0.48 |
| ▸ | MMP16 | P51512 | 3/20 | 0.47 |
| ▸ | MMP12 | P39900 | 2/20 | 0.47 |
| ▸ | BCL2L1 | Q07817 | 2/20 | 0.44 |
| ▸ | CCR5 | P51681 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | MTOR | P42345 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | RORC | P51449 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6323688 | 0.82 | ADAMTS4 (0.56) | ADAMTS4MMP2MMP9MMP8MMP14 | |
| SCHEMBL6325914 | 0.80 | ADAM17 (0.54) | ADAMTS4MMP2MMP9MMP8MMP14 | |
| SCHEMBL6328877 | 0.78 | CA2 (0.45) | MMP9MMP3MMP13MMP1ADAM17 | |
| SCHEMBL15705773 | 0.74 | MMP1 (0.54) | ADAMTS4MMP2MMP9MMP8MMP14 | |
| SCHEMBL6325908 | 0.72 | ADAMTS4 (0.58) | ADAMTS4MMP2MMP9MMP8MMP14 | |
| SCHEMBL6325911 | 0.72 | ADAMTS4 (0.58) | ADAMTS4MMP2MMP9MMP8MMP14 | |
| SCHEMBL6774616 | 0.70 | CCR5 (0.63) | MMP2MMP9MMP8MMP14MMP3 | |
| SCHEMBL15705805 | 0.70 | MMP1 (0.51) | ADAMTS4MMP2MMP9MMP8MMP14 | |
| SCHEMBL6323684 | 0.69 | ADAMTS4 (0.62) | ADAMTS4MMP2MMP9MMP8MMP14 | |
| SCHEMBL6323686 | 0.69 | ADAMTS4 (0.62) | ADAMTS4MMP2MMP9MMP8MMP14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050014840-A1 | Thiol sulfonamide metalloprotease inhibitors | PHARMACIA CORPORATION | 2005-01-20 | — | — | US | disclosed |
| US-6747027-B1 | SELECTIVELY INHIBITS IN VITRO ACTIVITY OF HUMAN MATRIX METALLOPROTEASE-13 OVER IN VITRO ACTIVITY OF HUMAN MATRIX METALLOPROTEASE-1 | PHARMACIA CORPORATION | 2004-06-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050014840-A1 | Thiol sulfonamide metalloprotease inhibitors | MMP12, MMP13, MMP3 | ADAMTS4 33/4885MMP2 26/4885MMP9 11/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.