Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGLL | Q99685 | 11/20 | 0.38 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.33 |
| ▸ | FAAH | O00519 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | NQO2 | P16083 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.31 |
| ▸ | HTR3A | P46098 | 2/20 | 0.31 |
| ▸ | CCR6 | P51684 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4847504 | 0.73 | PRKCG (0.41) | MGLLTLR9 | |
| SCHEMBL6345530 | 0.72 | MGLL (0.50) | MGLLTLR9HSP90AA1FAAHKDM4E | |
| SCHEMBL4845035 | 0.71 | PRKCB (0.45) | MGLLTLR9ALDH1A1MAPTL3MBTL1 | |
| SCHEMBL5688433 | 0.69 | TLR9 (0.50) | MGLLTLR9FAAHKMT2AALDH1A1 | |
| SCHEMBL4849912 | 0.69 | HSP90AA1 (0.58) | MGLLTLR9HSP90AA1FAAHNPC1 | |
| Hydrochloric Acid SCHEMBL31061545 | 0.68 | TLR9 (0.48) | MGLLTLR9FAAHKMT2AALDH1A1 | |
| SCHEMBL6348067 | 0.66 | TLR9 (0.40) | MGLLTLR9FAAHKDM4EALDH1A1 | |
| SCHEMBL6344199 | 0.66 | TLR9 (0.40) | MGLLTLR9FAAHKDM4EKMT2A | |
| SCHEMBL6345973 | 0.66 | MGLL (0.45) | MGLLTLR9HSP90AA1KDM4EKMT2A | |
| SCHEMBL6353710 | 0.65 | MGLL (0.50) | MGLLTLR9FAAHKMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6849643-B2 | Indazolyl-substituted pyrroline compounds as kinase inhibitors | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2005-02-01 | — | — | US | disclosed |