Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | F2 | P00734 | 1/20 | 0.48 |
| ▸ | PPM1B | O75688 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.44 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.42 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.41 |
| ▸ | HTR3B | O95264 | 1/20 | 0.41 |
| ▸ | HTR3A | P46098 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL637664 | 1.00 | LMNA (0.48) | LMNAF2PPM1BTDP1TSHR | |
| SCHEMBL1751897 | 1.00 | LMNA (0.48) | LMNAF2PPM1BTDP1TSHR | |
| SCHEMBL8458023 | 0.81 | TDP1 (0.50) | LMNATDP1KMT2ASMN1; SMN2MAPT | |
| SCHEMBL5692175 | 0.81 | TDP1 (0.50) | LMNATDP1KMT2ASMN1; SMN2MAPT | |
| SCHEMBL2969544 | 0.81 | TDP1 (0.50) | LMNATDP1KMT2ASMN1; SMN2MAPT | |
| SCHEMBL8461105 | 0.80 | PARP1 (0.46) | TDP1TSHRKMT2AMAPTALDH1A1 | |
| SCHEMBL2244028 | 0.77 | GAA (0.50) | LMNAF2TDP1TSHRKMT2A | |
| SCHEMBL8965206 | 0.77 | GAA (0.50) | LMNAF2TDP1TSHRKMT2A | |
| SCHEMBL23710673 | 0.76 | MEN1 (0.42) | LMNAF2PPM1BKMT2ACHRNA7 | |
| SCHEMBL9618911 | 0.76 | BCHE (0.48) | KMT2ACHRNA7MAPTMEN1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 53 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11370754-B2 | Method of preparing (3R,4S)-3-acetamido-4-allyl-n-(tert-butyl)pyrrolidine-3-carboxamide | CALITHERA BIOSCIENCES, INC. (US) | 2022-06-28 | — | — | US | disclosed |
| US-11370754-B2 | Method of preparing (3R,4S)-3-acetamido-4-allyl-n-(tert-butyl)pyrrolidine-3-carboxamide | CALITHERA BIOSCIENCES, INC. (US) | 2022-06-28 | — | — | US | disclosed |
| US-20210155589-A1 | METHOD OF PREPARING (3R,4S)-3-ACETAMIDO-4-ALLYL-N-(TERT-BUTYL)PYRROLIDINE-3-CARBOXAMIDE | CALITHERA BIOSCIENCES, INC. (US) | 2021-05-27 | — | — | US | disclosed |
| US-10906872-B2 | Method of preparing (3R,4S)-3-acetamido-4-allyl-n-(tert-butyl)pyrrolidine-3-carboxamide | CALITHERA BIOSCIENCES, INC. (US) | 2021-02-02 | — | — | US | disclosed |
| US-20200087255-A1 | METHOD OF PREPARING (3R,4S)-3-ACETAMIDO-4-ALLYL-N-(TERT-BUTYL)PYRROLIDINE-3-CARBOXAMIDE | CALITHERA BIOSCIENCES, INC. (US) | 2020-03-19 | — | — | US | disclosed |
| US-10385014-B2 | Acyloxyalkyl carbamate prodrugs, methods of synthesis and use | ARBOR PHARMACEUTICALS, LLC (US) | 2019-08-20 | — | — | US | disclosed |
| US-20180258032-A1 | ACYLOXYALKYL CARBAMATE PRODRUGS, METHODS OF SYNTHESIS AND USE | ARBOR PHARMACEUTICALS, LLC | 2018-09-13 | — | — | US | disclosed |
| US-9944592-B2 | Acyloxyalkyl carbamate prodrugs, methods of synthesis and use | XENOPORT, INC. (US) | 2018-04-17 | — | — | US | disclosed |
| US-20170190657-A1 | ACYLOXYALKYL CARBAMATE PRODRUGS, METHODS OF SYNTHESIS AND USE | XENOPORT, INC. (US) | 2017-07-06 | — | — | US | disclosed |
| US-9353057-B2 | Synthesis of acyloxyalkyl carbamate prodrugs and intermediates thereof | XENOPORT, INC. (US) | 2016-05-31 | — | — | US | disclosed |
| US-20050107334-A1 | Acyloxyalkyl carbamate prodrugs, methods of synthesis and use | XENOPORT, INC. | 2005-05-19 | — | — | US | disclosed |
| WO-2005019163-A2 | ACYLOXYALKYL CARBAMATE PRODRUGS, METHODS OF SYNTHESIS AND USE | XENOPORT, INC. (US) | 2005-03-03 | — | — | WO | disclosed |
| US-6706916-B1 | ESTERIFICATION OF OPTICALLY-ACTIVE AMINO ACIDS WITH BENZYL ALCOHOLS IN HYDRAZINE PRESENCE | TORAY FINE CHEMICALS CO., LTD. (JP) | 2004-03-16 | — | — | US | disclosed |
| EP-1156032-A1 | OPTICALLY ACTIVE AMINO ACID DERIVATIVES AND PROCESSES FOR THE PREPARATION OF THE SAME | TORAY INDUSTRIES, INC. (JP) | 2001-11-21 | — | — | EP | disclosed |
| EP-0600714-B1 | Process for producing O,O'-diacyltartaric anhydride and process for producing O,O'-diacyltartaric acid | TORAY INDUSTRIES (JP) | 1999-08-18 | — | — | EP | disclosed |
| EP-0924188-A1 | Production of 0,0'-diacyltartaric acid crystals | TORAY INDUSTRIES, INC. (JP) | 1999-06-23 | — | — | EP | disclosed |
| US-5512581-A | ANTIINFLAMMATORY AGENT | ABBOTT LABORATORIES (US) | 1996-04-30 | — | — | US | disclosed |
| US-5451687-A | Process for producing O,O'-diacyltartaric anhydride and process for producing O,O'-diacyltartaric acid | TORAY INDUSTRIES, INC. (JP) | 1995-09-19 | — | — | US | disclosed |
| EP-0600714-A1 | Process for producing O,O'-diacyltartaric anhydride and process for producing O,O'-diacyltartaric acid | TORAY INDUSTRIES, INC. (JP) | 1994-06-08 | — | — | EP | disclosed |
| US-5198449-A | N-substituted alpha-arylazacycloalkylmethanamines and their use as cardiovascular agents | A. H. ROBINS COMPANY INCORPORATED (US) | 1993-03-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10385014-B2 | Acyloxyalkyl carbamate prodrugs, methods of synthesis and use | APEH, ABAT, SI | LMNA 3875/4885F2 1924/4885PPM1B 2580/4885 |
| US-20180258032-A1 | ACYLOXYALKYL CARBAMATE PRODRUGS, METHODS OF SYNTHESIS AND USE | APEH, ABAT, SI | LMNA 3875/4885F2 1924/4885PPM1B 2580/4885 |
| US-20200087255-A1 | METHOD OF PREPARING (3R,4S)-3-ACETAMIDO-4-ALLYL-N-(TERT-BUTYL)PYRROLIDINE-3-CARBOXAMIDE | TERT, CTPS1, CTPS2 | LMNA 2152/4885F2 3581/4885PPM1B 4240/4885 |
| US-20170190657-A1 | ACYLOXYALKYL CARBAMATE PRODRUGS, METHODS OF SYNTHESIS AND USE | APEH, ABAT, SI | LMNA 3875/4885F2 1924/4885PPM1B 2580/4885 |
| US-10906872-B2 | Method of preparing (3R,4S)-3-acetamido-4-allyl-n-(tert-butyl)pyrrolidine-3-carboxamide | TERT, CTPS1, CTPS2 | LMNA 2152/4885F2 3581/4885PPM1B 4240/4885 |
| US-11370754-B2 | Method of preparing (3R,4S)-3-acetamido-4-allyl-n-(tert-butyl)pyrrolidine-3-carboxamide | TERT, CTPS1, CTPS2 | LMNA 2152/4885F2 3581/4885PPM1B 4240/4885 |
| US-20050107334-A1 | Acyloxyalkyl carbamate prodrugs, methods of synthesis and use | APEH, ABAT, SI | LMNA 3875/4885F2 1924/4885PPM1B 2580/4885 |
| US-20210155589-A1 | METHOD OF PREPARING (3R,4S)-3-ACETAMIDO-4-ALLYL-N-(TERT-BUTYL)PYRROLIDINE-3-CARBOXAMIDE | TERT, CTPS1, CTPS2 | LMNA 2152/4885F2 3581/4885PPM1B 4240/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.