Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
| ▸ | PGK1 | P00558 | 1/20 | 0.30 |
| ▸ | PGK2 | P07205 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11659880 | 0.97 | LMNA (0.38) | LMNATHRBCA2 | |
| SCHEMBL20560921 | 0.97 | LMNA (0.38) | LMNATHRBCA2 | |
| SCHEMBL21906292 | 0.97 | LMNA (0.38) | LMNATHRBCA2 | |
| SCHEMBL4352610 | 0.90 | PGK1 (0.32) | PGK1PGK2 | |
| SCHEMBL21983648 | 0.81 | — | — | |
| SCHEMBL11663909 | 0.80 | PGK1 (0.30) | PGK1PGK2 | |
| SCHEMBL1574291 | 0.75 | THRB (0.31) | LMNATHRB | |
| SCHEMBL442637 | 0.75 | PGK1 (0.52) | LMNATHRBCA2PGK1PGK2 | |
| SCHEMBL1574285 | 0.75 | THRB (0.31) | LMNATHRB | |
| SCHEMBL1542142 | 0.75 | PGK1 (0.39) | LMNATHRBCA2PGK1PGK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8962892-B2 | Process for the preparation of tris(perfluoroalkyl)phosphine oxides | MERCK PATENT GMBH (DE) | 2015-02-24 | — | — | US | claimed |
| US-9346838-B2 | Process for the preparation of tris(perfluoroalkyl)phosphine oxides and bis(perfluoroalkyl)phosphinic acids | MERCK PATENT GMBH (DE) | 2016-05-24 | — | — | US | disclosed |
| US-9056881-B2 | Process for the preparation of phosphinic acid esters | MERCK PATENT GMBH (DE) | 2015-06-16 | — | — | US | disclosed |
| US-20150141698-A1 | PROCESS FOR THE PREPARATION OF TRIS(PERFLUOROALKYL)PHOSPHINE OXIDES AND BIS(PERFLUOROALKYL)PHOSPHINIC ACIDS | MERCK PATENT GMBH (DE) | 2015-05-21 | — | — | US | disclosed |
| US-8962892-B2 | Process for the preparation of tris(perfluoroalkyl)phosphine oxides | MERCK PATENT GMBH (DE) | 2015-02-24 | — | — | US | disclosed |
| US-20150045572-A1 | PROCESS FOR THE PREPARATION OF PHOSPHINIC ACID ESTERS | MERCK PATENT GMBH (DE) | 2015-02-12 | — | — | US | disclosed |
| US-20120330063-A1 | PROCESS FOR THE PREPARATION OF TRIS(PERFLUOROALKYL)PHOSPHINE OXIDES | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2012-12-27 | — | — | US | disclosed |
| US-20050119513-A1 | Method for perfluoroalkylation by means of tris (perfluoroalkyl) phosphine oxides | MERCK PATENT GMBH (DE) | 2005-06-02 | — | — | US | disclosed |
| US-4124456-A | FLUORINATION | YAGUPOLSKY LEV M | 1978-11-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150045572-A1 | PROCESS FOR THE PREPARATION OF PHOSPHINIC ACID ESTERS | PHOSPHO1, ALK, PTEN | LMNA 2525/4885THRB 2716/4885CA2 282/4885 |
| US-20150141698-A1 | PROCESS FOR THE PREPARATION OF TRIS(PERFLUOROALKYL)PHOSPHINE OXIDES AND BIS(PERFLUOROALKYL)PHOSPHINIC ACIDS | PHOSPHO1, PFKFB4, PFKFB1 | LMNA 3912/4885THRB 532/4885CA2 269/4885 |
| US-20120330063-A1 | PROCESS FOR THE PREPARATION OF TRIS(PERFLUOROALKYL)PHOSPHINE OXIDES | PHOSPHO1, PFAS, CDIPT | LMNA 3815/4885THRB 651/4885CA2 70/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.