Benzenethiol

Benzenethiol

SCHEMBL6400615

O.Sc1ccccc1.Sc1ccccc1

nearest known ligand 0.40

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ABCC9ABL1ACEACHEACVR1ADORA1ADORA2AADORA2BADORA3ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALOX5ATP4AATP4BBCRBTKCACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGCRBNCUL4ACXCR1CXCR2DDB1DDCDHFRDPP4DRD2DRD3DRD4EGFRERBB2ERBB4ESR1ESR2FDPSFKBP1AFLT1FLT3FLT4GARTGHSRGRIA1GRIA2GRIA3GRIA4GRIK1GRIK2GRIK3GRIK4GRIK5GRIN2AGSK3AGSK3BHDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IDH1IDH2IMPA1ITGA2BITGB3JAK1JAK2JAK3KCNJ11KCNK3KCNK9KDRKITMEN1METMMP1MMP13MMP7MMP8NANOD2NS5bODC1OPG057OPRD1OPRK1OPRM1PPARP1PARP2PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PKLRPPARDPPATPTGS1PTGS2RBX1ROCK1ROCK2RRM1RRM2RRM2BSCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC10A2SLC5A2SLC6A2SLC6A3SLC6A4SLC9A3SYKTACR1THRATHRBTOP1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYK2TYMSVDRampCblablaT-3blaT-4blaT-5blaT-6blaUOE-1dacAdacBdacCfolAfolPftsIgyrAgyrBileSmecAmrcAmrcBmrdAparCparEpbp2pbp4pbpApbpFrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUthyAykgMykgO

The experimentally established mechanism targets of Benzenethiol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ACHE known ✓ P22303 1/20 0.35
HDAC8 known ✓ Q9BY41 1/20 0.35
ALDH1A1 P00352 4/20 0.40
IDO1 P14902 2/20 0.39
TSHR P16473 5/20 0.37
CA1 P00915 3/20 0.35
CA2 P00918 3/20 0.35
CA9 Q16790 3/20 0.35
TDP1 Q9NUW8 3/20 0.35
CA12 O43570 2/20 0.35
CA3 P07451 2/20 0.35
CA4 P22748 2/20 0.35
CA14 Q9ULX7 2/20 0.35
ALOX12 P18054 2/20 0.35
CA7 P43166 2/20 0.35
GLA P06280 1/20 0.35
LMNA P02545 1/20 0.35
MAPT P10636 2/20 0.35
HSD17B10 Q99714 2/20 0.33
CYP2A6 P11509 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Benzenethiol SCHEMBL27413317 1.00
Benzenethiol SCHEMBL15809974 0.96
Benzenethiol SCHEMBL28862443 0.96 ALDH1A1 (0.43) ALDH1A1IDO1TSHRCA1CA2
SCHEMBL22047568 0.96 ALDH1A1 (0.43) ALDH1A1IDO1TSHRCA1CA2
Benzenethiol SCHEMBL10796991 0.96 ALDH1A1 (0.43) ALDH1A1IDO1TSHRCA1CA2
Benzenethiol SCHEMBL2574156 0.96 ALDH1A1 (0.43) ALDH1A1IDO1TSHRCA1CA2
Benzenethiol SCHEMBL67 0.96
Benzenethiol SCHEMBL490106 0.96 ALDH1A1 (0.43) ALDH1A1IDO1TSHRCA1CA2
Benzenethiol SCHEMBL28175977 0.93 TSHR (0.39) ALDH1A1IDO1TSHRCA1CA2
Benzenethiol SCHEMBL20523592 0.92

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 35 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8450358-B2 Enantiomers of spiro-oxindole compounds and their uses as therapeutic agents XENON PHARMACEUTICALS INC. (CA) 2013-05-28 US claimed
US-8449602-B2 Methods for using a stent having nanoporous layers MEDTRONIC VASCULAR, INC. (US) 2013-05-28 US claimed
JP-4103568-A None JP disclosed
WO-2021198191-A1 QUINAZOLINONE DERIVATIVES AND USES THEREOF FOR TREATING A CANCER ENYO PHARMA (FR) 2021-10-07 WO disclosed
CN-113025409-A Diesel engine oil complexing agent and preparation method thereof 东风嘉实多油品有限公司 2021-06-25 CN disclosed
CN-109627264-B Target mitochondrial perylene anhydride fluorescent probe and synthetic method and application thereof 河北大学 2021-01-05 CN disclosed
EP-3500555-A1 HIGH REFRACTIVE INDEX LIQUIDS BASED ON META-SUBSTITUTED S-ALKYL THIOETHERS BASF SE (DE) 2019-06-26 EP disclosed
US-20190169157-A1 HIGH REFRACTIVE INDEX LIQUIDS BASED ON META-SUBSTITUTED S-ALKYL THIOETHERS BASF SE (DE) 2019-06-06 US disclosed
US-10287245-B2 Liquid thioether carboxylic acid esters BASF SE (DE) 2019-05-14 US disclosed
US-20180127363-A1 LIQUID THIOETHER CARBOXYLIC ACID ESTERS BASF SE (DE) 2018-05-10 US disclosed
WO-2018033493-A1 HIGH REFRACTIVE INDEX LIQUIDS BASED ON META-SUBSTITUTED S-ALKYL THIOETHERS BASF SE (DE) 2018-02-22 WO disclosed
CN-1382120-A Method of producing n-(4,5-bis-(methanesulfonyl)-2-methyl-benzoyl)-guanidine, hydrochloride thereof MERCK PATENT GMBH (DE) 2002-11-27 CN disclosed
EP-0934330-A1 BASE-PROTECTED NUCLEOTIDE ANALOGS WITH PROTECTED THIOL GROUPS Hanna, Michelle M. (US) 1999-08-11 EP disclosed
WO-1998003532-A9 BASE-PROTECTED NUCLEOTIDE ANALOGS WITH PROTECTED THIOL GROUPS 1998-05-28 WO disclosed
WO-1998003532-A1 BASE-PROTECTED NUCLEOTIDE ANALOGS WITH PROTECTED THIOL GROUPS HANNA MICHELLE M (US) 1998-01-29 WO disclosed
JP-H04103568-A THIOPHENOL ESTER AND DEVICE OF MEASURING HYDROLASE USING THE SAME THIOPHENOL ETHER TERUMO CORP 1992-04-06 JP disclosed
US-4829101-A SHELL-CORE POLYMERS ROHM GMBH (DE) 1989-05-09 US disclosed
US-4710525-A SHELL-CORE ROHM GMBH (DE) 1987-12-01 US disclosed
US-4186017-A Light-sensitive copying composition HOECHST AKTIENGESELLSCHAFT (DE) 1980-01-29 US disclosed
US-4021243-A Diazo light-sensitive copying composition and process of using in the manufacture of screen printing stencils HOECHST AKTIENGESELLSCHAFT (DT) 1977-05-03 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20180127363-A1 LIQUID THIOETHER CARBOXYLIC ACID ESTERS ALAD, TIPRL, CA7 ACHE 1562/4885HDAC8 535/4885ALDH1A1 1899/4885
US-20190169157-A1 HIGH REFRACTIVE INDEX LIQUIDS BASED ON META-SUBSTITUTED S-ALKYL THIOETHERS VSIR, LBR, TRRAP ACHE 1853/4885HDAC8 425/4885ALDH1A1 2434/4885
US-10287245-B2 Liquid thioether carboxylic acid esters ALAD, TIPRL, CA7 ACHE 1562/4885HDAC8 535/4885ALDH1A1 1899/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.