Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 1/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | GRM5 | P41594 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL65299 | 0.79 | LTA4H (0.35) | NPC1RAB9AL3MBTL1KDM4ETSHR | |
| SCHEMBL65814 | 0.79 | PPARG (0.39) | NPC1RAB9ASMN1; SMN2L3MBTL1KDM4E | |
| SCHEMBL66855 | 0.78 | ELANE (0.38) | — | |
| SCHEMBL65232 | 0.73 | TMEM97 (0.37) | — | |
| SCHEMBL66293 | 0.72 | PPM1B (0.32) | — | |
| SCHEMBL64034 | 0.71 | CHRM5 (0.38) | NPC1HPGDRAB9ASMN1; SMN2L3MBTL1 | |
| SCHEMBL4462269 | 0.70 | RIPK1 (0.36) | SLC6A2SLC6A4SLC6A3RIPK1 | |
| SCHEMBL15951884 | 0.70 | RIPK1 (0.36) | RIPK1 | |
| SCHEMBL65230 | 0.69 | MAPT (0.33) | NPC1L3MBTL1TSHR | |
| SCHEMBL18586707 | 0.68 | RIPK1 (0.33) | KDM4ERIPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8129538-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-06 | — | — | US | disclosed |