Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30435493 | 1.00 | NOS1 (0.54) | NOS1DHFR | |
| SCHEMBL31143797 | 1.00 | NOS1 (0.54) | NOS1DHFR | |
| Hydrochloric Acid SCHEMBL479239 | 0.98 | NOS1 (0.52) | NOS1DHFR | |
| Bromide SCHEMBL2553255 | 0.98 | NOS1 (0.52) | NOS1DHFR | |
| Bromide SCHEMBL1116048 | 0.98 | NOS1 (0.52) | NOS1DHFR | |
| Bromide SCHEMBL30761717 | 0.98 | NOS1 (0.52) | NOS1DHFR | |
| Bromide SCHEMBL29515501 | 0.98 | NOS1 (0.52) | NOS1DHFR | |
| Bromide SCHEMBL29695506 | 0.98 | NOS1 (0.52) | NOS1DHFR | |
| Bromide SCHEMBL28577318 | 0.97 | NOS1 (0.51) | NOS1DHFR | |
| Isopropyl Alcohol SCHEMBL8445236 | 0.89 | NOS1 (0.49) | NOS1DHFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 212 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2258702-A2 | Purified compositions of 10-Propargyl-10-Deazaaminopterin and method of using same in the treatment of tumors | Sloan-Kettering Institute For Cancer Research (US) | 2010-12-08 | — | — | EP | claimed |
| US-20100305134-A1 | SPECIFIC INHIBITORS OF PTERIDINE REDUCTASE WITH ANTIPARASITIC ACTION | TYDOCK PHARMA S.R.L. (IT) | 2010-12-02 | — | — | US | claimed |
| EP-2234998-A2 | SPECIFIC INHIBITORS OF PTERIDINE REDUCTASE WITH ANTIPARASITIC ACTION | Tydock Pharma S.r.l. (IT) | 2010-10-06 | — | — | EP | claimed |
| WO-2009080367-A2 | SPECIFIC INHIBITORS OF PTERIDINE REDUCTASE WITH ANTIPARASITIC ACTION | TYDOCKPHARMA S.R.L. (IT) | 2009-07-02 | — | — | WO | claimed |
| EP-1891957-A1 | Purified Compositions of 10-Propargyl-10-Deazaaminopterin and Methods of Using Same in the Treament of Tumors | Sloan-Kettering Institute for Cancer Research (US) | 2008-02-27 | — | — | EP | claimed |
| EP-0527185-B1 | AMETHOPTERIN(METHOTREXATE) PRO-DRUGS, INTERMEDIATE PRODUCTS, A PREPARATION METHOD, AND COMPOSITIONS CONTAINING THEM | BRITISH TECH GROUP (GB) | 1995-04-12 | — | — | EP | claimed |
| EP-0006123-B1 | A PTERIDINE DERIVATIVE AND A PROCESS FOR THE PREPARATION OF 10-DEAZAAMINOPTERIN AND ITS DERIVATIVES FROM THE PTERIDINE DERIVATIVE | Southern Research Institute (US) | 1985-01-16 | — | — | EP | claimed |
| US-4421913-A | SOLVENT EXTRACTION | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 1983-12-20 | — | — | US | claimed |
| US-4224446-A | Process for the production of methotrexate | LONZA LTD. (CH) | 1980-09-23 | — | — | US | claimed |
| US-4079056-A | REACTING 2,4-DIAMINO-6-PTERIDINE-METHANOL-HBR WITH TRIPHENYLPHOSPHINE DIBROMIDE OR PHOSPHORUS TRIBROMIDE | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH, EDUCATION AND WELFARE (US) | 1978-03-14 | — | — | US | claimed |
| US-12421187-B2 | Dihydrofolate synthase (DHFS) inhibiting agents and methods of making and using same | WASHINGTON UNIVERISTY (US) | 2025-09-23 | — | — | US | disclosed |
| US-20250114466-A1 | ANTIFOLATE LINKER-DRUGS AND ANTIBODY-DRUG CONJUGATES | BYONDIS B.V. (NL) | 2025-04-10 | — | — | US | disclosed |
| EP-4457229-A1 | ANTIFOLATE LINKER-DRUGS AND ANTIBODY-DRUG CONJUGATES | Byondis B.V. (NL) | 2024-11-06 | — | — | EP | disclosed |
| US-20230406859-A1 | METHOTREXATE ANALOGS AND METHODS OF USE | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPT. OF HEALTH AND HUMAN SERVICES (US) | 2023-12-21 | — | — | US | disclosed |
| US-20230322667-A1 | DIHYDROFOLATE SYNTHASE (DHFS) INHIBITING AGENTS AND METHODS OF MAKING AND USING SAME | WASHINGTON UNIVERSITY (US) | 2023-10-12 | — | — | US | disclosed |
| US-4421913-A | SOLVENT EXTRACTION | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 1983-12-20 | — | — | US | disclosed |
| US-4224446-A | Process for the production of methotrexate | LONZA LTD. (CH) | 1980-09-23 | — | — | US | disclosed |
| US-4224446-A | Process for the production of methotrexate | LONZA LTD. (CH) | 1980-09-23 | — | — | US | disclosed |
| US-4079056-A | REACTING 2,4-DIAMINO-6-PTERIDINE-METHANOL-HBR WITH TRIPHENYLPHOSPHINE DIBROMIDE OR PHOSPHORUS TRIBROMIDE | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH, EDUCATION AND WELFARE (US) | 1978-03-14 | — | — | US | disclosed |
| US-4077957-A | INTERMEDIATE FOR METHOTREXATE | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH, EDUCATION AND WELFARE (US) | 1978-03-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230406859-A1 | METHOTREXATE ANALOGS AND METHODS OF USE | MTX1, MTX2, MGMT | NOS1 268/4885DHFR 9/4885 |
| US-20250114466-A1 | ANTIFOLATE LINKER-DRUGS AND ANTIBODY-DRUG CONJUGATES | DHFR, FOLR1, MTHFD2 | NOS1 4167/4885DHFR 1/4885 |
| US-20230322667-A1 | DIHYDROFOLATE SYNTHASE (DHFS) INHIBITING AGENTS AND METHODS OF MAKING AND USING SAME | DHFR, DHPS, MTHFD1 | NOS1 2595/4885DHFR 1/4885 |
| US-20100305134-A1 | SPECIFIC INHIBITORS OF PTERIDINE REDUCTASE WITH ANTIPARASITIC ACTION | QDPR, DHFR, DDC | NOS1 1167/4885DHFR 2/4885 |
| US-12421187-B2 | Dihydrofolate synthase (DHFS) inhibiting agents and methods of making and using same | DHFR, DHPS, MTHFD1 | NOS1 2595/4885DHFR 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.