Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | SLC22A12 | Q96S37 | 3/20 | 0.32 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.32 |
| ▸ | GRM5 | P41594 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | NAMPT | P43490 | 1/20 | 0.31 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.31 |
| ▸ | PLIN1 | O60240 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7364415 | 1.00 | AKR1C1 (0.37) | AKR1C1SLC6A2SLC6A4SLC6A3NPSR1 | |
| Hydrochloric Acid SCHEMBL1357987 | 0.98 | AKR1C1 (0.36) | AKR1C1SLC6A2SLC6A4SLC6A3NPSR1 | |
| Bromide SCHEMBL7340605 | 0.98 | AKR1C1 (0.36) | AKR1C1SLC6A2SLC6A4SLC6A3NPSR1 | |
| Bromide SCHEMBL7342624 | 0.84 | EPHX1 (0.38) | SLC6A2SLC6A4SLC6A3ALDH1A1HPGD | |
| Bromide SCHEMBL7347333 | 0.79 | ELANE (0.40) | SLC6A2SLC6A3NPSR1ALDH1A1HPGD | |
| SCHEMBL7366551 | 0.78 | OPRM1 (0.32) | — | |
| SCHEMBL10969403 | 0.76 | SLC6A2 (0.37) | AKR1C1SLC6A2SLC6A4SLC6A3ALDH1A1 | |
| SCHEMBL18280875 | 0.76 | AKR1C1 (0.34) | AKR1C1SLC6A2SLC6A4SLC6A3NPSR1 | |
| SCHEMBL7380300 | 0.76 | ELANE (0.31) | — | |
| SCHEMBL11234892 | 0.72 | ALDH1A1 (0.39) | AKR1C1ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 61 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2389360-A2 | A PROCESS FOR THE PREPARATION OF ZOFENOPRIL AND ITS PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF | Glenmark Generics Limited (IN) | 2011-11-30 | — | — | EP | claimed |
| US-20110253651-A1 | Drying rack with wrap-around cover | BEHJAT MOHAMMAD KAZEM | 2011-10-20 | — | — | US | claimed |
| WO-2010084515-A2 | A PROCESS FOR THE PREPARATION OF ZOFENOPRIL AND ITS PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF | GLENMARK GENERICS LIMITED (IN) | 2010-07-29 | — | — | WO | claimed |
| EP-1102745-B1 | A PROCESS FOR THE PREPARATION OF ZOFENOPRIL CALCIUM SALT | MENARINI INT OPERATIONS LU SA (LU) | 2004-05-12 | — | — | EP | claimed |
| US-6521760-B1 | Process for the preparation of zofenopril calcium salt | MENARINI RICHERCHE S.P.A. (IT) | 2003-02-18 | — | — | US | claimed |
| JP-2002522417-A | — | — | 2002-07-23 | — | — | JP | claimed |
| EP-1102745-A1 | A PROCESS FOR THE PREPARATION OF ZOFENOPRIL CALCIUM SALT | Menarini International Operations Luxembourg S.A. (LU) | 2001-05-30 | — | — | EP | claimed |
| WO-2000007984-A1 | A PROCESS FOR THE PREPARATION OF ZOFENOPRIL CALCIUM SALT | MENARINI RICERCHE S.P.A. (IT) | 2000-02-17 | — | — | WO | claimed |
| US-4482725-A | ANGIOTENSIN CONVERTING ENZYME INHIBITOR | E. R. SQUIBB & SONS, INC. (US) | 1984-11-13 | — | — | US | claimed |
| EP-2245007-B1 | Process for preparing a crystalline form of zofenopril calcium | GENERICS UK LTD (GB) | 2020-08-19 | — | — | EP | disclosed |
| US-9221754-B2 | Crystalline forms of zofenopril calcium | GENERICS [UK] LIMITED (GB) | 2015-12-29 | — | — | US | disclosed |
| EP-1899297-B1 | ZOFENOPRIL CALCIUM IN POLYMORPH FORM C | GENERICS UK LTD (GB) | 2015-12-09 | — | — | EP | disclosed |
| EP-2173710-B1 | NOVEL CRYSTALLINE FORM | GENERICS UK LTD (GB) | 2015-09-16 | — | — | EP | disclosed |
| US-20140378523-A1 | NOVEL CRYSTALLINE FORMS OF ZOFENOPRIL CALCIUM | TIANISH LABORATORIES PRIVATE LIMITED (IN) | 2014-12-25 | — | — | US | disclosed |
| US-4337201-A | Phosphinylalkanoyl substituted prolines | E. R. SQUIBB & SONS, INC. (US) | 1982-06-29 | — | — | US | disclosed |
| EP-0053902-A1 | Phosphinylalkanoyl substituted prolines | E.R. Squibb & Sons, Inc. (US) | 1982-06-16 | — | — | EP | disclosed |
| EP-0052991-A1 | Carboxyalkyl amino acid derivatives of various substituted prolines | E.R. Squibb & Sons, Inc. (US) | 1982-06-02 | — | — | EP | disclosed |
| EP-0049589-A1 | Carboxyalkanoyl and hydroxycarbamoylalkanoyl derivatives of substituted prolines | E.R. Squibb & Sons, Inc. (US) | 1982-04-14 | — | — | EP | disclosed |
| US-4316906-A | HYPOTENSIVE AGENTS | E. R. SQUIBB & SONS, INC. (US) | 1982-02-23 | — | — | US | disclosed |
| US-4311705-A | HYPOTENSIVE AGENTS | E. R. SQUIBB & SONS, INC. (US) | 1982-01-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140378523-A1 | NOVEL CRYSTALLINE FORMS OF ZOFENOPRIL CALCIUM | REN, ACE, CA2 | AKR1C1 2474/4885SLC6A2 1267/4885SLC6A4 334/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.