Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 7/20 | 0.44 |
| ▸ | FAAH | O00519 | 2/20 | 0.43 |
| ▸ | CES1 | P23141 | 1/20 | 0.43 |
| ▸ | DAGLA | Q9Y4D2 | 1/20 | 0.43 |
| ▸ | XDH | P47989 | 3/20 | 0.42 |
| ▸ | MMP1 | P03956 | 1/20 | 0.41 |
| ▸ | MMP2 | P08253 | 1/20 | 0.41 |
| ▸ | MMP3 | P08254 | 1/20 | 0.41 |
| ▸ | PRSS8 | Q16651 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | CTSL | P07711 | 1/20 | 0.37 |
| ▸ | CTSB | P07858 | 1/20 | 0.37 |
| ▸ | CTSK | P43235 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | CCR1 | P32246 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6463414 | 1.00 | CTSS (0.44) | CTSSFAAHCES1DAGLAXDH | |
| SCHEMBL6463782 | 0.87 | CTSS (0.43) | CTSSFAAHCES1DAGLAXDH | |
| SCHEMBL6467110 | 0.86 | CTSS (0.44) | CTSSFAAHCES1CTSKNPC1 | |
| SCHEMBL6466904 | 0.84 | DAGLA (0.50) | FAAHCES1DAGLAXDHPRSS8 | |
| SCHEMBL6467344 | 0.83 | PRSS8 (0.45) | CTSSFAAHCES1DAGLAMMP1 | |
| SCHEMBL6473317 | 0.81 | MMP1 (0.40) | CTSSFAAHCES1DAGLAXDH | |
| SCHEMBL6465885 | 0.81 | XDH (0.47) | CTSSFAAHCES1DAGLAXDH | |
| SCHEMBL6472179 | 0.80 | MMP3 (0.44) | CTSSFAAHCES1MMP1MMP2 | |
| SCHEMBL5671486 | 0.80 | CTSS (0.39) | CTSSFAAHCES1DAGLAXDH | |
| SCHEMBL6467360 | 0.79 | CNR1 (0.49) | MMP1MMP2MMP3NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1516877-A1 | Amine derivatives as protease inhibitors | AXYS PHARMACEUTICALS, INC. (US) | 2005-03-23 | — | — | EP | disclosed |