Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNN4 | O15554 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | CES1 | P23141 | 1/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | TTR | P02766 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | ESR1 | P03372 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19884937 | 0.80 | SMN1; SMN2 (0.47) | KCNN4ALDH1A1ALOX15CYP2C19CYP1A2 | |
| SCHEMBL7066085 | 0.79 | MAPK1 (0.42) | KCNN4ALDH1A1ALOX15MAPK1CES1 | |
| SCHEMBL28979286 | 0.78 | ALDH1A1 (0.45) | KCNN4ALDH1A1ALOX15CYP2C19CYP1A2 | |
| SCHEMBL670716 | 0.77 | CES1 (0.40) | KCNN4ALDH1A1ALOX15CYP2C19CYP1A2 | |
| SCHEMBL3205224 | 0.77 | ALOX15 (0.43) | KCNN4ALDH1A1ALOX15CYP2C19CYP1A2 | |
| SCHEMBL2368149 | 0.76 | KCNN4 (0.36) | KCNN4ALDH1A1ALOX15CYP2C19CYP1A2 | |
| SCHEMBL6490060 | 0.75 | CYP2C19 (0.45) | KCNN4ALDH1A1ALOX15CYP2C19CYP1A2 | |
| SCHEMBL235054 | 0.75 | MAPK1 (0.42) | KCNN4ALDH1A1ALOX15MAPK1CES1 | |
| SCHEMBL5972484 | 0.75 | KIF11 (0.43) | KCNN4ALDH1A1ALOX15MAPK1SMN1; SMN2 | |
| SCHEMBL28018766 | 0.75 | CYP2C19 (0.43) | KCNN4ALDH1A1ALOX15CYP2C19CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050009886-A1 | 1,4-Dihydropyridine derivative with a guaiacoxypropanolamine and/or phenoxypropanolamine moiety | CHEN ING-JUN (TW) | 2005-01-13 | — | — | US | disclosed |
| US-6794399-B2 | BETA-ADRENORECEPTOR AND CALCIUM CHANNEL BLOCKING AGENT; INDUCED VASORELAXING EFFECT | CHEN ING-JUN (TW) | 2004-09-21 | — | — | US | disclosed |
| US-20020156109-A1 | 1,4-dihydropyridine derivative with a guaiacoxypropanolamine and/or phenoxypropanolamine moiety | CHEN ING-JUN (TW) | 2002-10-24 | — | — | US | disclosed |
| EP-1108710-A1 | GUAIACOXYPROPANOLAMINES WITH ALPHA/BETA-ADRENERGIC BLOCKING ACTIVITY | Cheng, Ing-Jun (TW) | 2001-06-20 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020156109-A1 | 1,4-dihydropyridine derivative with a guaiacoxypropanolamine and/or phenoxypropanolamine moiety | ADRA1D, ADRA2C, ADRB3 | KCNN4 417/4885ALDH1A1 303/4885ALOX15 1510/4885 |
| US-20050009886-A1 | 1,4-Dihydropyridine derivative with a guaiacoxypropanolamine and/or phenoxypropanolamine moiety | ADRB3, ADRB1, ADRA1D | KCNN4 39/4885ALDH1A1 707/4885ALOX15 849/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.