Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDO2 | P48775 | 14/20 | 0.45 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.41 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 2/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.38 |
| ▸ | HTR1D | P28221 | 1/20 | 0.38 |
| ▸ | HTR1B | P28222 | 1/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.38 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6503216 | 0.86 | TDO2 (0.50) | TDO2SLC6A4OPRL1DRD2HTR2A | |
| SCHEMBL6492149 | 0.81 | TDO2 (0.46) | TDO2SLC6A4OPRL1DRD2HTR2A | |
| SCHEMBL4878519 | 0.80 | TDO2 (0.57) | TDO2SLC6A4OPRL1DRD2HTR2A | |
| SCHEMBL20111756 | 0.77 | HTR2A (0.46) | SLC6A4HTR2AADRA1DADRA1AADRA1B | |
| SCHEMBL18129577 | 0.75 | JAK2 (0.38) | TDO2SLC6A4 | |
| SCHEMBL6334848 | 0.73 | GYS1 (0.34) | — | |
| SCHEMBL6340611 | 0.73 | LMNA (0.33) | DRD2HTR2AHTR1DHTR1B | |
| SCHEMBL6339270 | 0.72 | GYS1 (0.37) | HTR1D | |
| SCHEMBL820521 | 0.72 | GPR84 (0.41) | SLC6A4DRD2HTR2A | |
| SCHEMBL7090614 | 0.72 | DRD2 (0.49) | SLC6A4OPRL1DRD2HTR2AADRA1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6844338-B2 | Piperidyindoles as serotonin receptor ligands | ELI LILLY AND COMPANY (US) | 2005-01-18 | — | — | US | disclosed |
| US-20030225068-A1 | Piperidyindoles as serotonin receptor ligands | ELI LILLY AND COMPANY | 2003-12-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030225068-A1 | Piperidyindoles as serotonin receptor ligands | CNR1, HTR1D, HTR1A | TDO2 1463/4885SLC6A4 215/4885OPRL1 32/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.